{"title":"HLA-B27相关视神经炎1例","authors":"Matar Alexandre , Ibrikji Sidonie , Bou Ghannam Alaa","doi":"10.1016/j.nerep.2022.100155","DOIUrl":null,"url":null,"abstract":"<div><p>We report the case of a young woman who presented with chronic relapsing inflammatory optic neuritis (CRION) in association with HLA-B27 and silent brain lesions. The attacks were refractory to steroids but no further attacks occurred on treatment with mycophenolate mofetil. This is one of the few HLA-B27-associated optic neuritis cases reported in the literature, emphasizing the relation of HLA-B27 and inflammation of the brain and optic nerve, as well as the role mycophenolate mofetil might offer in stabilizing the disease.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"3 ","pages":"Article 100155"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Case of HLA-B27-associated optic neuritis\",\"authors\":\"Matar Alexandre , Ibrikji Sidonie , Bou Ghannam Alaa\",\"doi\":\"10.1016/j.nerep.2022.100155\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We report the case of a young woman who presented with chronic relapsing inflammatory optic neuritis (CRION) in association with HLA-B27 and silent brain lesions. The attacks were refractory to steroids but no further attacks occurred on treatment with mycophenolate mofetil. This is one of the few HLA-B27-associated optic neuritis cases reported in the literature, emphasizing the relation of HLA-B27 and inflammation of the brain and optic nerve, as well as the role mycophenolate mofetil might offer in stabilizing the disease.</p></div>\",\"PeriodicalId\":100950,\"journal\":{\"name\":\"Neuroimmunology Reports\",\"volume\":\"3 \",\"pages\":\"Article 100155\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroimmunology Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667257X22001012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimmunology Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667257X22001012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
We report the case of a young woman who presented with chronic relapsing inflammatory optic neuritis (CRION) in association with HLA-B27 and silent brain lesions. The attacks were refractory to steroids but no further attacks occurred on treatment with mycophenolate mofetil. This is one of the few HLA-B27-associated optic neuritis cases reported in the literature, emphasizing the relation of HLA-B27 and inflammation of the brain and optic nerve, as well as the role mycophenolate mofetil might offer in stabilizing the disease.
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