F. Garridol , M. Perez , M.D. Torres , E. Garcia-Olivares , P. Ivanyi , V. Schirrmacher
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A Syngeneic Anti Tumor Serum Recognizing a Complex H-2 Alloantigen
A methylcholanthrene induced tumor of BALBc (H-2d) origin had a high rate of spontaneous regression when transplanted into syngeneic animals. The tumor induced in BALB/c mice iso-antibodies with high anti-tumor cytotoxic activity. A specificity analysis of such BALB/c anti MCG4 sera revealed that the antibodies were directed against a tumor antigen which is very similar to H-2-aIIoantigens (e.g. H-2.5) expressed on normal cens of certain foreign mouse strains. The sera also reacted with nine out of ten B10.W congenic strains bearing H-2wi haplotypes derived from wild mice.
Whether the tumor antigen is identical with foreign H-2 antigens or only cross-reactive cannot be decided at present.
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