Salvage Cryoablation of the Prostate for Patients with Radiation Failure: An Overview

The rationale for salvage cryoablation of the prostate for patients with recurrent prostate cancer following radiation therapy failure is reviewed. The history and recent developments of cryosurgery are discussed, along with mechanisms of action. The current prostate cryoablation technique is outlined, in conjunction with patient selection criteria, inherent challenges, and advantages to this procedure compared with other salvage procedures. Recent modifications in the cryoablation technique make it an acceptable treatment option for those patients in whom radiation therapy has failed. Evidence from prospective randomized clinical trials is still needed.