{"title":"网络警告:药物输送中的微生物","authors":"Lawrence P. Wackett*","doi":"10.1111/1751-7915.14251","DOIUrl":null,"url":null,"abstract":"<p>Microbe-based drug delivery.</p><p>\n https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895346/\n </p><p>This review targets microbe-based drug delivery with the goal of providing site-specific medical benefits to patients.</p><p>Synthetic microbes as drug delivery systems.</p><p>\n https://pubs.acs.org/doi/10.1021/sb500258b\n </p><p>This article examines potential developments in medicine for using microbes to diagnose disease, produce therapeutics in situ, and deliver medicines.</p><p>Microbial-fabricated nano-systems.</p><p>\n https://www.frontiersin.org/articles/10.3389/fchem.2021.617353/full\n </p><p>This is a broad treatment on the formulations of microbes with metals, polysaccharides, and other agents for making nano-scale delivery agents.</p><p>Modes of therapeutic delivery.</p><p>\n https://www.cell.com/trends/microbiology/fulltext/S0966-842X(22)00249-9\n </p><p>This review discusses bacterial therapeutics and vaccines, with a focus on those moving into clinical trials.</p><p>Bacteria and anti-cancer drugs.</p><p>\n https://www.sciencedirect.com/science/article/pii/S0168365920303849\n </p><p>This review article highlights the use of bacteria or bacterial derivatives as drug carriers for cancer therapy.</p><p>Bacterial drug delivery IP.</p><p>\n https://www.wipo.int/wipo_magazine/en/2014/04/article_0002.html\n </p><p>This interesting article in the World International Patent Organization (WIPO) magazine discusses a microbial drug patented for the treatment of gastrointestinal disorders.</p><p>Bacterial lysing systems in cancer therapy.</p><p>\n https://www.nature.com/articles/s41467-021-26367-9\n </p><p>This article deals with the use of a <i>Salmonella</i>-derived delivery system to induce lysis and release proteins specifically into tumour cells.</p><p>Bacteria and medical implants.</p><p>\n https://www.mdpi.com/2079-4983/13/4/173\n </p><p>This deals with bacterially responsive drug delivery for the release of antibacterial compounds at the site of implants to mitigate against infections.</p><p>Anti-microbial peptide delivery.</p><p>\n https://agris.fao.org/agris-search/search.do?recordID=US202000140612\n </p><p>Nano-scale drug delivery systems are being investigated for the delivery of bacterially produced toxins called bacteriocins.</p>","PeriodicalId":49145,"journal":{"name":"Microbial Biotechnology","volume":"16 4","pages":"868"},"PeriodicalIF":4.8000,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.14251","citationCount":"0","resultStr":"{\"title\":\"Web alert: Microbes in drug delivery\",\"authors\":\"Lawrence P. 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This interesting article in the World International Patent Organization (WIPO) magazine discusses a microbial drug patented for the treatment of gastrointestinal disorders.
This article deals with the use of a Salmonella-derived delivery system to induce lysis and release proteins specifically into tumour cells.
Bacteria and medical implants.
https://www.mdpi.com/2079-4983/13/4/173
This deals with bacterially responsive drug delivery for the release of antibacterial compounds at the site of implants to mitigate against infections.
期刊介绍：
Microbial Biotechnology publishes papers of original research reporting significant advances in any aspect of microbial applications, including, but not limited to biotechnologies related to: Green chemistry; Primary metabolites; Food, beverages and supplements; Secondary metabolites and natural products; Pharmaceuticals; Diagnostics; Agriculture; Bioenergy; Biomining, including oil recovery and processing; Bioremediation; Biopolymers, biomaterials; Bionanotechnology; Biosurfactants and bioemulsifiers; Compatible solutes and bioprotectants; Biosensors, monitoring systems, quantitative microbial risk assessment; Technology development; Protein engineering; Functional genomics; Metabolic engineering; Metabolic design; Systems analysis, modelling; Process engineering; Biologically-based analytical methods; Microbially-based strategies in public health; Microbially-based strategies to influence global processes
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