CD56蛋白表达降低在甲状腺乳头状癌中的诊断价值

Won Young Park, Seong Muk Jeong, Jung Hee Lee, Hyun Jeong Kang, Dong Hun Sin, Kyung Un Choi, Do Youn Park, Gi Yeong Huh, Mee Young Sol, Chang Hun Lee
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引用次数: 29

摘要

背景与目的:准确的病理诊断对甲状腺肿瘤的最佳治疗至关重要。辅助诊断标记在某些情况下可能会有所帮助。本研究的目的是比较和评价CD56、细胞角蛋白19 (CK19)和半乳糖凝集素-3免疫组化染色在鉴别乳头状癌(PC)及其他甲状腺恶性病变和良性病变中的诊断价值。方法:分别在PC(67例)、滤泡性癌(FC, 23例)、髓样癌(MC, 18例)、间变性癌(AC, 4例)、滤泡性腺瘤(FA, 15例)、结节性增生(NH, 21例)中检测3种标志物的表达。结果:统计分析显示,除AC外,CD56、半凝集素-3、CK19在PC中的表达与甲状腺其他病变有显著差异,其中CD56诊断PC的敏感性为92.5%,特异性为86.4%。CD56在鉴别PC与甲状腺其他病变方面的诊断特异性高于半凝集素-3或CK19。但其敏感性低于半乳糖凝集素-3和CK19。结论:CD56是诊断PC的良好阴性标志物。我们建议用于PC诊断的免疫组化面板应包括CD56、半乳糖凝集素-3和CK19。
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Diagnostic value of decreased expression of CD56 protein in papillary carcinoma of the thyroid gland

Background and aims: Precise pathological diagnosis is essential for optimal treatment of thyroid tumors. Ancillary diagnostic markers may be helpful in some cases. The purpose of this study was to compare and evaluate the diagnostic value of CD56, cytokeratin 19 (CK19), and galectin-3 immunohistochemical stainings in distinguishing between papillary carcinoma (PC) and other thyroid malignancies and benign lesions. Methods: The expressions of the three markers were evaluated in PC (n= 67), follicular carcinoma (FC, n= 23), medullary carcinoma (MC, n= 18), anaplastic carcinoma (AC, n= 4), follicular adenoma (FA, n= 15), and nodular hyperplasia (NH, n= 21). Results: Statistical analysis showed significantly different expressions of CD56, galectin-3, and CK19 in PC versus other lesions of the thyroid gland, with the exception of AC. Especially, the sensitivity and specificity of CD56 for diagnosing PC were 92.5% and 86.4%, respectively. The diagnostic specificity of CD56 was higher than that of galectin-3 or CK19 in differentiating PC from other lesions of the thyroid gland. However, its sensitivity was lower than that of galectin-3 or CK19. Conclusion: CD56 turns out to be a good negative marker for diagnosing PC. We suggest that immunohistochemical panels directed at the diagnosis of PC should include CD56 together with galectin-3 and CK19.

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