Yoon Jin Cha, Myoung Ju Koh, Young Tae Kim, Nam Hoon Cho
{"title":"层状黏液产生上皮内病变","authors":"Yoon Jin Cha, Myoung Ju Koh, Young Tae Kim, Nam Hoon Cho","doi":"10.1111/j.1755-9294.2012.01132.x","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>We report a case of stratified mucin producing intraepithelial lesion (SMILE), associated with adenocarcinoma and human papillomavirus (HPV) 18 infection. A 54-year-old lady presented with vaginal bleeding for 2 months. A punchy biopsy in private clinic showed papillary neoplasm composed of stratified columnar epithelium showing intracytoplasmic mucin vacuole. Microscopic examination for following cone biopsy demonstrated adenocarcinoma along with SMILE, and HPV 18 was detected by DNA chip examination. After several immunohistochemical stainings, SMILE showed predominant glandular differentiation.</p>\n </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 3","pages":"72-75"},"PeriodicalIF":0.0000,"publicationDate":"2012-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2012.01132.x","citationCount":"3","resultStr":"{\"title\":\"Stratified mucin producing intraepithelial lesion\",\"authors\":\"Yoon Jin Cha, Myoung Ju Koh, Young Tae Kim, Nam Hoon Cho\",\"doi\":\"10.1111/j.1755-9294.2012.01132.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>We report a case of stratified mucin producing intraepithelial lesion (SMILE), associated with adenocarcinoma and human papillomavirus (HPV) 18 infection. A 54-year-old lady presented with vaginal bleeding for 2 months. A punchy biopsy in private clinic showed papillary neoplasm composed of stratified columnar epithelium showing intracytoplasmic mucin vacuole. Microscopic examination for following cone biopsy demonstrated adenocarcinoma along with SMILE, and HPV 18 was detected by DNA chip examination. After several immunohistochemical stainings, SMILE showed predominant glandular differentiation.</p>\\n </div>\",\"PeriodicalId\":92990,\"journal\":{\"name\":\"Basic and applied pathology\",\"volume\":\"5 3\",\"pages\":\"72-75\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-08-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1755-9294.2012.01132.x\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Basic and applied pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/j.1755-9294.2012.01132.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basic and applied pathology","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1755-9294.2012.01132.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
We report a case of stratified mucin producing intraepithelial lesion (SMILE), associated with adenocarcinoma and human papillomavirus (HPV) 18 infection. A 54-year-old lady presented with vaginal bleeding for 2 months. A punchy biopsy in private clinic showed papillary neoplasm composed of stratified columnar epithelium showing intracytoplasmic mucin vacuole. Microscopic examination for following cone biopsy demonstrated adenocarcinoma along with SMILE, and HPV 18 was detected by DNA chip examination. After several immunohistochemical stainings, SMILE showed predominant glandular differentiation.
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