紫杉醇C环的对映选择性合成

Cong Ma, Stéphanie Schiltz, Joëlle Prunet
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引用次数: 5

摘要

完成了紫杉醇C环的对映选择性合成。关键步骤是氧化裂解一个衍生的威兰-米歇尔酮。第一次尝试夏皮罗反应模拟C环与紫杉醇A片段的耦合也取得了成功。©2011中国科学院有机化学与生物化学研究所。
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Enantioselective synthesis of a taxol C ring
An enantioselective synthesis of a C ring of taxol has been accomplished. The key step is an oxidative cleavage of a derivative of the Wieland-Miescher ketone. A first attempt of a Shapiro reaction modelling the coupling of the C ring with the A fragment of taxol was also successful. © 2011 Institute of Organic Chemistry and Biochemistry.
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