A case of Cronkhite-Canada syndrome with hypogeusia

Cronkhite-Canada syndrome (CCS) is a rare, sporadically occurring and non-familial syndrome. We report a case of CCS with hypogeusia. A 68-year-old male was suffering from diarrhea and anorexia. Endoscopic examination revealed gastrointestinal polyposis. He visited our clinic complaining of taste disturbance. Together with hyperpigmentation of skin, nail dystrophy and smooth tongue, he was diagnosed as CCS. The patient was treated with predonine and then zinc sulfate. Two months later, taste score was greatly improved. The gastrointestinal polyps were found to have disappeared at 4 months and the blood zinc concentration to have recovered at 6 months after treatment. The patients progress remains good about 5 years later.