S. Natarajan, Mary A. Smith, Cody J. Wehrkamp, Ashley M. Mohr, J. Mott
{"title":"MicroRNA在人类疾病中的功能","authors":"S. Natarajan, Mary A. Smith, Cody J. Wehrkamp, Ashley M. Mohr, J. Mott","doi":"10.1159/000356447","DOIUrl":null,"url":null,"abstract":"MicroRNAs are emerging as a hot topic in research, and rightfully so. They show great promise as targets of treatment and as markers for common human diseases, such as cancer and metabolic diseases. In this review, we address some of the basic questions regarding microRNA function in human disease and the clinical significance of microRNAs. Specifically, microRNAs in epigenetics, cancer, and metabolic diseases are discussed, with examples taken from cholangiocarcinoma and nonalcoholic fatty liver disease.","PeriodicalId":90260,"journal":{"name":"Medical epigenetics","volume":"1 1","pages":"106 - 115"},"PeriodicalIF":0.0000,"publicationDate":"2013-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000356447","citationCount":"18","resultStr":"{\"title\":\"MicroRNA Function in Human Diseases\",\"authors\":\"S. Natarajan, Mary A. Smith, Cody J. Wehrkamp, Ashley M. Mohr, J. Mott\",\"doi\":\"10.1159/000356447\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"MicroRNAs are emerging as a hot topic in research, and rightfully so. They show great promise as targets of treatment and as markers for common human diseases, such as cancer and metabolic diseases. In this review, we address some of the basic questions regarding microRNA function in human disease and the clinical significance of microRNAs. Specifically, microRNAs in epigenetics, cancer, and metabolic diseases are discussed, with examples taken from cholangiocarcinoma and nonalcoholic fatty liver disease.\",\"PeriodicalId\":90260,\"journal\":{\"name\":\"Medical epigenetics\",\"volume\":\"1 1\",\"pages\":\"106 - 115\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-11-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000356447\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical epigenetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000356447\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical epigenetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000356447","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
MicroRNAs are emerging as a hot topic in research, and rightfully so. They show great promise as targets of treatment and as markers for common human diseases, such as cancer and metabolic diseases. In this review, we address some of the basic questions regarding microRNA function in human disease and the clinical significance of microRNAs. Specifically, microRNAs in epigenetics, cancer, and metabolic diseases are discussed, with examples taken from cholangiocarcinoma and nonalcoholic fatty liver disease.
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