erg介导的细胞侵袭:发展与肿瘤发生之间的联系

Medical epigenetics Pub Date : 2015-10-14 DOI:10.1159/000440978

Alexandra M. Blee, Haojie Huang

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引用次数: 3

摘要

转录因子ERG在血管生成和血管生成、血管完整性和造血干细胞维持的发育过程中是重要的。在成人中，ERG仅在内皮细胞中表达，并在发育中发挥类似的作用，介导血管形成。然而，成人中ERG的异常过表达会导致前列腺癌等疾病，而ERG在肿瘤发生中的分子和细胞机制仍不清楚。对ERG阳性前列腺癌的研究表明，ERG促进细胞侵袭和转移，导致患者预后不良。总之，这些研究揭示了ERG介导的细胞侵袭是发育过程中正常ERG功能与前列腺癌中致癌ERG功能之间的潜在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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ERG-Mediated Cell Invasion: A Link between Development and Tumorigenesis

The transcription factor ERG is important during development for vasculogenesis and angiogenesis, blood vessel integrity, and maintenance of hematopoietic stem cells. In human adults, ERG is only expressed in endothelial cells and performs similar roles as in development to mediate blood vessel formation. However, aberrant overexpression of ERG in the adult contributes to diseases like prostate cancer, and the molecular and cellular mechanisms of ERG in tumorigenesis remain largely unclear. Studies of ERG-positive prostate cancers have shown that ERG promotes cell invasion and metastasis and contributes to poor patient prognosis. Together, these studies reveal ERG-mediated cell invasion as a potential link between normal ERG function in development and oncogenic ERG function in prostate cancer.

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