Successful Hematopoietic stem cell transplantation (HSCT) from matched unrelated donor (MUD) in a pediatric patient using myeloablative regimen suffering from MDS: case report from western India.

Myelodysplastic syndrome (MDS) is heterogeneous hematopoietic stem cell disorders characterized by ineffective erythropoiesis and dyserythropoiesis. Allogenic HSCT from siblings in our country in pediatric MDS is very well documented. But HSCT from matched unrelated donor (MUD) in paediatric age is still a new concept to implement in our country. We are here presenting the relapse case of MDS (myelodysplastic syndrome) and we had done successful HSCT from MUD in a 14 year old paediatric patient. Myeloablative regimen (fludarabine, busulfan, cyclophosphamide, ATG) was used during HSCT. 100% donor chimerism was found on +day 34 VNTR study. Patient is doing well 1year after HSCT without any complications.