腰骶后路融合术后局部创面内应用万古霉素的不良反应

Q3 Medicine Hirurgia Pozvonochnika Pub Date : 2018-06-09 DOI:10.14531/SS2018.2.76-83
V. Byvaltsev, I. Stepanov, V. Borisov
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引用次数: 3

摘要

目标。目的分析腰骶椎后路减压稳定术后局部伤口内应用万古霉素粉的不良反应类型及发生频率。材料和方法。分析2011-2017年发表的临床丛书。在第一阶段,使用关键词“伤口万古霉素”、“手术部位感染”和“腰椎后路融合”搜索Medline和PubMed数据库的英文文献来源,并使用“万古霉素粉的局部应用”、“手术部位感染”和“后路减压和稳定”搜索俄语文献来源的电子图书馆。在第二阶段,对文章的摘要进行审查,不符合研究标准的出版物被排除在外。在第三阶段,审查选定文章的全文是否符合纳入标准,以及相关研究的参考文献。结果。19项临床研究(16项回顾性研究,3项前瞻性研究)共13077例患者入选系统评价。在55.3%(7236例)的腰骶后路手术病例中,局部应用万古霉素粉剂预防手术部位感染。在整个队列患者中,2.19%的患者检测到不良药物反应。结论。局部应用万古霉素粉剂与不良药物反应发生率低有关。
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ADVERSE DRUG REACTIONS TO LOCAL INTRAWOUND VANCOMYCIN APPLICATION AFTER POSTERIOR LUMBOSACRAL FUSION
Objective. To analyze the types and frequency of adverse drug reactions to local intrawound application of vancomycin powder in patients after posterior decompression and stabilization in the lumbosacral spine. Material and Methods . Clinical series published in 2011–2017 were analyzed. At the first stage, Medline and PubMed databases were searched for English-language literature sources using the keywords «intrawound vancomycin», «surgical site infection», and «posterior lumbar fusion», and e-Library for Russian-language sources using «local application of vancomycin powder», «infection in the surgical site», and «posterior decompression and stabilization». At the second stage, abstracts of articles were examined, and publications that did not meet the research criteria were excluded. At the third stage, the full texts of the selected articles were reviewed for compliance with inclusion criteria, as well as references for relevant studies. Results. Nineteen clinical studies (16 retrospective and 3 prospective) with a total of 13,077 patients were selected for a systematic review. In 55.3 % (7,236) of posterior lumbosacral surgery cases, vancomycin powder was applied locally to prevent surgical site infection. Among the entire cohort of patients, unwanted drug reactions were detected in 2.19 % of patients. Conclusions. Local application of vancomycin powder is associated with a low incidence of unwanted drug reactions.
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来源期刊
Hirurgia Pozvonochnika
Hirurgia Pozvonochnika Medicine-Anesthesiology and Pain Medicine
CiteScore
0.60
自引率
0.00%
发文量
24
审稿时长
7 weeks
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