性别对自闭症谱系障碍儿童唾液抗氧化能力和氧化损伤影响的初步研究

Matheus Morcela de Souza, J. V. S. Rodrigues, Maria Eduarda Cabrerizo Gonçalves, Ana Carolina Polanowski Rossato, M. Stein, M. Poli, L. Theodoro, A. C. Nakamune
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引用次数: 2

摘要

自闭症是一种复杂的神经系统疾病,具有多因素的病因,损害了身体、心理、情感和社交技能。这种疾病还会损害牙齿护理和患者的口腔健康。唾液可以很容易地通过非侵入性技术获得,并已用于许多疾病的诊断和筛查。儿童龋齿时,唾液的总抗氧化能力会降低,这可能是自闭症的标志。然而,关于自闭症谱系障碍(ASD)儿童唾液抗氧化剂的数据很少。目的探讨性别对小儿唾液非酶抗氧化能力和蛋白质氧化损伤的影响。我们的假设是,这些生化参数在自闭症儿童中存在性别差异。材料与方法在上午8:00-11:00抽取12名5 - 15岁的女孩和12名男孩的全唾液样本,既往诊断为该疾病。分光光度法测定总抗氧化能力、尿酸、蛋白质浓度及对蛋白质的氧化损伤。数值以均数±标准差表示,并检验是否符合正态性(Shapiro-Wilk检验)。然后使用Mann-Whitney检验对数据进行比较,考虑5%的显著性水平。结果各组间各项分析参数比较,差异均无统计学意义(P < 0.05)。结论基于所获得的结果,我们得出结论,性别不影响ASD儿童唾液中氧化应激标志物的水平。
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Gender influence on antioxidant capacity and oxidative damage in saliva of children with autism spectrum disorder: a preliminary study
Abstract Introduction Autism is a complex neurological disorder with multifactorial causes, which compromises physical, psychological, emotional and social skills. This disorder also impairs dental care and patient oral health. Saliva can be easily obtained using a non-invasive technique and has been used in the diagnosis and screening of many pathologies. Total antioxidant capacity of saliva is reduced in the presence of caries in children and has been studied as a possible marker for autism. However, data on salivary antioxidants in children with autism spectrum disorder (ASD) is scarce. Objective This preliminary study evaluated the existence of gender influence on non-enzymatic antioxidant capacity and protein oxidative damage in the saliva of children with this disorder. Our hypothesis is that there are gender differences in these biochemical parameters in children with austim. Material and method Whole saliva samples were collected by aspiration between 8:00-11:00 am from 12 girls and 12 boys aged 5 to 15 years, with previous diagnosis for this disorder. Total antioxidant capacity, uric acid, protein concentration and oxidative damage to proteins were analyzed by spectrophotometry. Values were presented as mean ± standard deviation and tested for adherence to normality (Shapiro-Wilk test). The data were then compared using the Mann-Whitney test, considering a 5% significance level. Result There was no significant difference between groups for all analyzed parameters (P>0.05). Conclusion Based on the results obtained, we concluded that gender does not influence the levels of oxidative stress markers in the saliva of children with ASD.
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