3-羟基卡铂，一种简单的卡铂衍生物，具有改进的毒理学特征

Platinum Metals Review Pub Date : 2012-10-01 DOI:10.1595/147106712X654204

K. Kasem, D. Ager, F. Nerozzi, Weiping Liu, Xi-zhu Chen, Qingsong Ye, Shuqian Hou, L. Lou, Xie Chengying

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引用次数: 15

摘要

3-羟基卡铂(3-Hydroxycarboplatin)是一种简单的卡铂衍生物，采用新方法合成，并对其体外和体内抗癌活性进行了表征和评价。它具有与卡铂相当的抗肿瘤活性，但毒性要低得多，特别是在骨髓抑制方面，显示出作为一种新的抗肿瘤铂类药物取代卡铂的巨大潜力。

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3-Hydroxycarboplatin, a Simple Carboplatin Derivative Endowed with an Improved Toxicological Profile

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China *Email: liguanglou1@126.com 3-Hydroxycarboplatin, a simple carboplatin derivative, was synthesised using a novel method, characterised and evaluated for its anticancer activity in vitro and in vivo. It shows comparable antitumour activity to that of carboplatin but has much lower toxicity particularly with respect to myelosuppression, revealing great potential for development as a new antitumour platinum drug to replace carboplatin.

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Platinum Metals Review CHEMISTRY, PHYSICAL-

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>12 weeks