Electrochemical Evaluation of Catalytic Effect of Aluminum in Oxidation the Paracetamol in Human Blood

The reactivity of paracetamol (Pa) using the carbon paste electrode (CPE) modified by the aluminum (CPE-Al) was reported. The working electrode was prepared by mixing the aluminum with the carbon powder. The optimal potential window was selected from -1.7 V to 1.7 V. The effect of parameters such as pH, scan rate, accumulation time and concentration were affected by cyclic voltammetry (CV) and square wave voltammetry (SWV). The optimal preconcentration time is 8 minutes. The reactivity of Pa on the electroanalysis detector was characterized by the appearance of the anodic peak at 0.25 V in a solution of sodium sulfate (0.1 M, pH 7). The calculated limits of detection and quantification have been 8.28·10-9 and 2.74·10-8 mol L-1, respectively. Then relative standard deviation (RSD) at 2.0·10-5 mol L-1 Pa concentration was 4.08 % for nine repetitions. The analytical application was carried out in the detection of Pa in human blood with satisfying results.