Pyridoxamine improves diabetes-evoked delayed bone repair in mice

Diabetes mellitus is a metabolic disorder, and its prevalence is increasing worldwide. It is a major cause of cardiovascular disease, stroke, chronic kidney disease, neuropathy, blindness, and cancer, which are closely associated with morbidity and mortality in patients with diabetes. Diabetes has also been recognized to affect bone health in terms of bone strength, turnover, mineral density, and structure. Delayed bone healing is recognized as an additional complication of longstanding diabetes, which is associated with a high risk of delayed union, non-union, or pseudoarthrosis [1-3]. Prevention and improvement of the disabling bone complications in diabetes have attracted more attention.