{"title":"植物复合不育剂通过FAM209调控PICK1在大鼠中的作用","authors":"Chundan Shi","doi":"10.17582/journal.pjz/20221017071041","DOIUrl":null,"url":null,"abstract":"This animal study aimed to investigate the regulatory effect of FAM209, and PICK1protein in SD rats with Rodent pest. SD rats are randomly divided into control group, low (10 mg/kg of plant complex sterility agent) and high dose (20 mg/kg of plant complex sterility agent) groups. Hematoxylin and eosin staining is used to observe the pathological changes of testis tissue. The testis organ index, male seminal vesicle, and sperm were also detected. The expression of FAM209, and PICK1protein in testis tissue are detected by Western blotting. Compared with the control group, the cell structure in the testis tissue of the model group is damaged, and testis organ index, male seminal vesicle, the sperm density level in the control group, low dose group are significantly increased ( P <0.05). The results of WB confirm the expression of FAM209 ( P <0.05). downregulated of FAM209, and PICK1protein may be involved in the development of rodent pest.","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Role of Plant Complex Sterility Agent in Rats via FAM209 Regulating PICK1\",\"authors\":\"Chundan Shi\",\"doi\":\"10.17582/journal.pjz/20221017071041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This animal study aimed to investigate the regulatory effect of FAM209, and PICK1protein in SD rats with Rodent pest. SD rats are randomly divided into control group, low (10 mg/kg of plant complex sterility agent) and high dose (20 mg/kg of plant complex sterility agent) groups. Hematoxylin and eosin staining is used to observe the pathological changes of testis tissue. The testis organ index, male seminal vesicle, and sperm were also detected. The expression of FAM209, and PICK1protein in testis tissue are detected by Western blotting. Compared with the control group, the cell structure in the testis tissue of the model group is damaged, and testis organ index, male seminal vesicle, the sperm density level in the control group, low dose group are significantly increased ( P <0.05). The results of WB confirm the expression of FAM209 ( P <0.05). downregulated of FAM209, and PICK1protein may be involved in the development of rodent pest.\",\"PeriodicalId\":19975,\"journal\":{\"name\":\"Pakistan Journal of Zoology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pakistan Journal of Zoology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.17582/journal.pjz/20221017071041\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ZOOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Zoology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.17582/journal.pjz/20221017071041","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ZOOLOGY","Score":null,"Total":0}
The Role of Plant Complex Sterility Agent in Rats via FAM209 Regulating PICK1
This animal study aimed to investigate the regulatory effect of FAM209, and PICK1protein in SD rats with Rodent pest. SD rats are randomly divided into control group, low (10 mg/kg of plant complex sterility agent) and high dose (20 mg/kg of plant complex sterility agent) groups. Hematoxylin and eosin staining is used to observe the pathological changes of testis tissue. The testis organ index, male seminal vesicle, and sperm were also detected. The expression of FAM209, and PICK1protein in testis tissue are detected by Western blotting. Compared with the control group, the cell structure in the testis tissue of the model group is damaged, and testis organ index, male seminal vesicle, the sperm density level in the control group, low dose group are significantly increased ( P <0.05). The results of WB confirm the expression of FAM209 ( P <0.05). downregulated of FAM209, and PICK1protein may be involved in the development of rodent pest.
期刊介绍：
Pakistan Journal of Zoology (Pakistan J. Zool.) publishes original articles in English on all aspects of animal life. Generally these articles will be in, or related to one of the following subject areas: Physiology, Cell Biology, Molecular Biology, Genetics, Bioinformatics, Toxicology, Forensic Science, Developmental Biology, Entomology, Parasitology, Microbiology, Biotechnology, Pathology, Palaeontology. Taxonomy, Environmental Biology, Wildlife, Fisheries, Vertebrate and Invertebrate Morphology. Additionally, the journal considers research on health and clinical studies. Short communications are regularly considered, however, uninvited review articles, first records/reports of known species, case reports/studies and survey reports are not published in Pakistan Journal of Zoology.
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