{"title":"maedii -visna病毒是HIV的模型","authors":"V. Andrésdóttir","doi":"10.16886/IAS.2018.03","DOIUrl":null,"url":null,"abstract":"Maedi-visna virus (MVV) is a lentivirus of sheep causing inflammation in many organs, primarily the lungs and CNS. HIV and SIV also belong to the lentivirus genus of retroviruses. MVV and HIV have many features in common, including genome organization, mode of virus replication, virus-host interaction and latency. Both viruses infect cells of the monocyte/macrophage lineage, but the main difference in cell tropism is that, whereas HIV infects T lymphocytes, MVV does not. Here, the molecular biology, cell tropism and pathogenesis of MVV are reviewed and some of the similarities as well as the dissimilarities between MVV and HIV are discussed.","PeriodicalId":50396,"journal":{"name":"Icelandic Agricultural Sciences","volume":"31 1","pages":"23-47"},"PeriodicalIF":0.2000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Maedi-visna virus as a model for HIV\",\"authors\":\"V. Andrésdóttir\",\"doi\":\"10.16886/IAS.2018.03\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Maedi-visna virus (MVV) is a lentivirus of sheep causing inflammation in many organs, primarily the lungs and CNS. HIV and SIV also belong to the lentivirus genus of retroviruses. MVV and HIV have many features in common, including genome organization, mode of virus replication, virus-host interaction and latency. Both viruses infect cells of the monocyte/macrophage lineage, but the main difference in cell tropism is that, whereas HIV infects T lymphocytes, MVV does not. Here, the molecular biology, cell tropism and pathogenesis of MVV are reviewed and some of the similarities as well as the dissimilarities between MVV and HIV are discussed.\",\"PeriodicalId\":50396,\"journal\":{\"name\":\"Icelandic Agricultural Sciences\",\"volume\":\"31 1\",\"pages\":\"23-47\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Icelandic Agricultural Sciences\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.16886/IAS.2018.03\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"AGRICULTURE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Icelandic Agricultural Sciences","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.16886/IAS.2018.03","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
Maedi-visna virus (MVV) is a lentivirus of sheep causing inflammation in many organs, primarily the lungs and CNS. HIV and SIV also belong to the lentivirus genus of retroviruses. MVV and HIV have many features in common, including genome organization, mode of virus replication, virus-host interaction and latency. Both viruses infect cells of the monocyte/macrophage lineage, but the main difference in cell tropism is that, whereas HIV infects T lymphocytes, MVV does not. Here, the molecular biology, cell tropism and pathogenesis of MVV are reviewed and some of the similarities as well as the dissimilarities between MVV and HIV are discussed.
期刊介绍：
Icelandic Agricultural Sciences is published annually, or more frequently. The deadline for submitting manuscripts that are intended to appear within that year is September. The journal is in English and is refereed and distributed internationally. It publishes original articles and reviews written by researchers throughout the world on any aspect of applied life sciences that are relevant under boreal, alpine, arctic or subarctic conditions. Relevant subjects include e.g. any kind of environmental research, farming, breeding and diseases of plants and animals, hunting and fisheries, food science, forestry, soil conservation, ecology of managed and natural ecosystems, geothermal ecology, etc.
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