{"title":"Thr92AlaD2多态性可能在甲状腺功能减退中起新作用","authors":"Elizabeth A. McAninch, A. Bianco","doi":"10.17925/USE.2015.11.02.92","DOIUrl":null,"url":null,"abstract":"The type 2 deiodinase (D2) has an important role in hypothyroidism, where its ability to activate thyroid hormone provides justification for levothyroxine “monotherapy.” A prevalent polymorphism in D2, Thr92AlaD2, has been associated with improved well-being on “combination therapy” with T4+T3; the underlying mechanism is unclear as T4-to-T3 conversion appears normal. Novel studies indicate this might be a risk factor for neurodegenerative disease. If the relationship between Thr92AlaD2-expression and treatment preference is confirmed, personalized medicine may play a role in hypothyroidism.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"11 1","pages":"92"},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"The Thr92AlaD2 Polymorphism May Play a Novel Role in Hypothyroidism\",\"authors\":\"Elizabeth A. McAninch, A. Bianco\",\"doi\":\"10.17925/USE.2015.11.02.92\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The type 2 deiodinase (D2) has an important role in hypothyroidism, where its ability to activate thyroid hormone provides justification for levothyroxine “monotherapy.” A prevalent polymorphism in D2, Thr92AlaD2, has been associated with improved well-being on “combination therapy” with T4+T3; the underlying mechanism is unclear as T4-to-T3 conversion appears normal. Novel studies indicate this might be a risk factor for neurodegenerative disease. If the relationship between Thr92AlaD2-expression and treatment preference is confirmed, personalized medicine may play a role in hypothyroidism.\",\"PeriodicalId\":23490,\"journal\":{\"name\":\"US endocrinology\",\"volume\":\"11 1\",\"pages\":\"92\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"US endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17925/USE.2015.11.02.92\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"US endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17925/USE.2015.11.02.92","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
The Thr92AlaD2 Polymorphism May Play a Novel Role in Hypothyroidism
The type 2 deiodinase (D2) has an important role in hypothyroidism, where its ability to activate thyroid hormone provides justification for levothyroxine “monotherapy.” A prevalent polymorphism in D2, Thr92AlaD2, has been associated with improved well-being on “combination therapy” with T4+T3; the underlying mechanism is unclear as T4-to-T3 conversion appears normal. Novel studies indicate this might be a risk factor for neurodegenerative disease. If the relationship between Thr92AlaD2-expression and treatment preference is confirmed, personalized medicine may play a role in hypothyroidism.
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