近交繁殖对代际肥胖表型的影响

Alais Ferreira da Rocha de Oliveria, José Rebuglio Vellosa, Bruno Hartmann, Yasmin Fidler, C. A. Reis, J. R. Gomes
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引用次数: 1

摘要

材料与方法:出生后减少窝数,公母各2窝,成年后进行近亲交配。将8只公鼠组成的正常窝群作为无亲缘组,与减少窝群的结果进行比较,评估以下肥胖表型:Lee指数、体重、食物摄入量、腹膜后脂肪沉积、小肠长度、杯状细胞数量,以及葡萄糖、胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和VLDL水平。
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Effects of the Inbreeding Reproduction on the Obesity Phenotypes Over Generations
Materials and Methods: Litters were reduced to 2 males and 2 females after birth and the consanguineous mating was performed in adulthood. A normal litter containing 8 males was used as no consanguineous group to compare the results with those of the reduced litters concerning to follows obesity phenotypes evaluated: Lee index, body mass, food intake, retroperitoneal fat deposit, length of the small intestine, goblet cells number, as well as for the glucose, cholesterol, triglycerides, LDL, HDL and VLDL levels.
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