不同性别青少年外源性体质性肥胖标准治疗期间脂质过氧化系统的变化

M. Darenskaya, L. V. Rychkova, S. Kolesnikov, O. Kravtsova, N. Semenova, A. Brichagina, L. Kolesnikova
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引用次数: 1

摘要

目标。揭示不同性别青少年外源性体质性肥胖标准非药物治疗背景下脂质过氧化参数和抗氧化保护成分的变化。患者和方法。在非药物治疗前后对46名12-17岁的肥胖青少年进行了检查。对照组包括36名健康青少年。我们分析了脂质过氧化产物-共轭二烯(CD)、酮二烯和共轭三烯(KD和CT)的组成、tba活性产物和抗氧化保护因子的活性:总抗氧化活性(AOA)、α-生育酚、视黄醇、还原性和氧化性谷胱甘肽(GSH、GSSG)水平、它们的比值(GSH/GSSG比值)、超氧化物歧化酶(SOD)活性。采用分光光度法和荧光法。结果。与对照组相比,肥胖男性青少年的主要脂质过氧化产物CD(1.35倍,p = 0.001)和抗氧化保护因子总AOA(1.16倍,p = 0.036)和SOD活性(1.49倍,p < 0.0001)值较低,而次要产物KD和CT(1.42倍,p = 0.046)升高。男性青少年的标准治疗并没有导致研究参数的正常化。外源性体质型肥胖女性青少年总AOA值(1.4倍,p = 0.0001)、SOD活性(1.42倍,p < 0.0001)和α-生育酚(1.33倍,p = 0.012)均显著低于对照组。标准治疗后,GSSG水平升高(1.14倍,p = 0.029)。结论。研究显示,肥胖青少年的促氧化和抗氧化状态出现了负面变化,经过一个疗程的标准治疗后,这种变化没有正常化。通过抗氧化药物的处方进行额外的药理学纠正变得相关。关键词:抗氧化保护;标准治疗;氧化应激
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Changes in lipid peroxidation system during standard therapy for exogenous constitutional obesity in adolescents of different sex
Objective. To reveal changes in lipid peroxidation parameters and antioxidant protection components against the background of standard non-pharmacological therapy for exogenous constitutional obesity in adolescents of different sex. Patients and methods. Forty-six adolescents aged 12–17 years with obesity were examined before and after non-pharmacological therapy. The control group included 36 healthy adolescents. We analyzed the composition of lipid peroxidation products – conjugated dienes (CD), ketodienes and conjugated trienes (KD and CT), TBA-active products and activity of antioxidant protection factors: total antioxidant activity (AOA), levels of α-tocopherol, retinol, reduced and oxidized glutathione (GSH, GSSG), their ratio (GSH/GSSG ratio), superoxide dismutase (SOD) activity. Spectrophotometric and fluorometric methods were used. Results. Male adolescents with obesity had lower values of primary lipid peroxidation products compared to the control group – CD (1.35-fold, p = 0,001) and antioxidant protection factors: total AOA (1.16-fold, p = 0,036) and SOD activity (1.49-fold, p < 0.0001), whereas secondary products – KD and CT were elevated (1.42-fold, p = 0,046). Standard therapy in male adolescents did not lead to normalization of the studied parameters. Significantly lower were the values of total AOA (1.4-fold, p = 0.0001), SOD activity (1.42-fold, p < 0.0001) and α-tocopherol (1.33-fold, p = 0.012) in female adolescents with exogenous constitutional obesity compared to the control group. After standard therapy, there was an increase in GSSG levels (1.14-fold, p = 0.029). Conclusion. The presence of negative changes in the pro- and antioxidant status in adolescents with obesity, which was not normalized after a course of standard therapy, was shown. Additional pharmacological correction by prescription of antioxidant drugs becomes relevant. Key words: antioxidant protection, standard therapy, oxidative stress, adolescents, exogenous constitutional obesity
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来源期刊
Voprosy Detskoi Dietologii
Voprosy Detskoi Dietologii Medicine-Pediatrics, Perinatology and Child Health
CiteScore
1.20
自引率
0.00%
发文量
17
期刊介绍: The scientific journal Voprosy Detskoi Dietologii is included in the Scopus database. Publisher country is RU. The main subject areas of published articles are Food Science, Pediatrics, Perinatology, and Child Health, Nutrition and Dietetics, Клиническая медицина.
期刊最新文献
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