O. Tumash, A. M. Karamyshau, I. Stoma, M. N. Menshakova, I. O. Vakulchik
{"title":"瑞德西韦对孕妇新型冠状病毒感染过程的影响","authors":"O. Tumash, A. M. Karamyshau, I. Stoma, M. N. Menshakova, I. O. Vakulchik","doi":"10.20953/1729-9225-2022-1-16-22","DOIUrl":null,"url":null,"abstract":"Objective. To estimate efficiency and safety of remdesivir in treating new coronavirus infection in pregnant. Materials and methods. A retrospective cohort study including 61 medical patient’s records who underwent COVID-19 and being pregnant more than 20 weeks was conducted. Medical case histories were divided into 2 groups: the main one with the use of remdesivir treatment (n = 35) and control one (n = 26) without it. The groups were representative by age, anthropometric data and comorbidity (p > 0.05). Results. The use of remdesivir in pregnant patients with COVID-19 causes a reduction in fever by 15% and achievement of target saturation values in 94.3% of cases, reduces С-reaction protein (CRP) levels by 3.5 times, D-dimer by 2.6, Lactat Dehydrogenase (LDG) by 1.4 times on 5th day from the moment of hospitalization, reduces its duration by 30.8%, does not affect the course of pregnancy and the frequency of Cesarean section. Conclusion. The use of remdesivir in the treatment of COVID-19 in pregnant patients with a gestation period of more than 20 weeks is effective, as evidenced by the shortening of the fever period, the duration of hospitalization, improving oxygenation, reduction of laboratory markers \"cytokine storm\" in blood levels and safe due to the lack of impact on pregnancy and delivery strategy. Key words: СOVID-19, cytokine storm, laboratory criteria, pregnancy, remdesivir","PeriodicalId":37794,"journal":{"name":"Infektsionnye Bolezni","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Remdesivir influence on course of new coronaviral infection in pregnant\",\"authors\":\"O. Tumash, A. M. Karamyshau, I. Stoma, M. N. Menshakova, I. O. Vakulchik\",\"doi\":\"10.20953/1729-9225-2022-1-16-22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective. To estimate efficiency and safety of remdesivir in treating new coronavirus infection in pregnant. Materials and methods. A retrospective cohort study including 61 medical patient’s records who underwent COVID-19 and being pregnant more than 20 weeks was conducted. Medical case histories were divided into 2 groups: the main one with the use of remdesivir treatment (n = 35) and control one (n = 26) without it. The groups were representative by age, anthropometric data and comorbidity (p > 0.05). Results. The use of remdesivir in pregnant patients with COVID-19 causes a reduction in fever by 15% and achievement of target saturation values in 94.3% of cases, reduces С-reaction protein (CRP) levels by 3.5 times, D-dimer by 2.6, Lactat Dehydrogenase (LDG) by 1.4 times on 5th day from the moment of hospitalization, reduces its duration by 30.8%, does not affect the course of pregnancy and the frequency of Cesarean section. Conclusion. The use of remdesivir in the treatment of COVID-19 in pregnant patients with a gestation period of more than 20 weeks is effective, as evidenced by the shortening of the fever period, the duration of hospitalization, improving oxygenation, reduction of laboratory markers \\\"cytokine storm\\\" in blood levels and safe due to the lack of impact on pregnancy and delivery strategy. Key words: СOVID-19, cytokine storm, laboratory criteria, pregnancy, remdesivir\",\"PeriodicalId\":37794,\"journal\":{\"name\":\"Infektsionnye Bolezni\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infektsionnye Bolezni\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20953/1729-9225-2022-1-16-22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infektsionnye Bolezni","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20953/1729-9225-2022-1-16-22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Remdesivir influence on course of new coronaviral infection in pregnant
Objective. To estimate efficiency and safety of remdesivir in treating new coronavirus infection in pregnant. Materials and methods. A retrospective cohort study including 61 medical patient’s records who underwent COVID-19 and being pregnant more than 20 weeks was conducted. Medical case histories were divided into 2 groups: the main one with the use of remdesivir treatment (n = 35) and control one (n = 26) without it. The groups were representative by age, anthropometric data and comorbidity (p > 0.05). Results. The use of remdesivir in pregnant patients with COVID-19 causes a reduction in fever by 15% and achievement of target saturation values in 94.3% of cases, reduces С-reaction protein (CRP) levels by 3.5 times, D-dimer by 2.6, Lactat Dehydrogenase (LDG) by 1.4 times on 5th day from the moment of hospitalization, reduces its duration by 30.8%, does not affect the course of pregnancy and the frequency of Cesarean section. Conclusion. The use of remdesivir in the treatment of COVID-19 in pregnant patients with a gestation period of more than 20 weeks is effective, as evidenced by the shortening of the fever period, the duration of hospitalization, improving oxygenation, reduction of laboratory markers "cytokine storm" in blood levels and safe due to the lack of impact on pregnancy and delivery strategy. Key words: СOVID-19, cytokine storm, laboratory criteria, pregnancy, remdesivir
期刊介绍:
The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.