牛初乳的抗菌和抗炎特性。

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics Recent patents on inflammation & allergy drug discovery Pub Date : 2016-03-31 DOI:10.2174/1872214810666160219163118
R. Yadav, T. Angolkar, Ginpreet Kaur, H. Buttar
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引用次数: 22

摘要

背景与社区有关的疾病是世界上疾病的主要原因之一。氧化应激和微生物感染在炎症性疾病中起主要作用。牛初乳(BC)含有免疫球蛋白和乳铁蛋白,有助于建立免疫力和防止细菌的增殖和生长。本研究旨在探讨BC的抗菌和抗炎活性。材料与方法采用倾倒平板法测定5种不同菌株(Gram -ve和+ve)的抗菌活性,采用角叉菜胶诱导大鼠足部水肿法评价成年Wistar大鼠的抗炎活性。以双氯芬酸为标准抗炎药,阿莫西林为标准抗菌药物。结果bc对埃希氏菌有明显的抑菌活性。杆菌、葡萄球菌。球菌、变形杆菌。甜菜属,肠杆菌属。气原菌和沙门氏菌。伤寒。当BC浓度为100µg/mL时,抑制区分别为13mm、11mm、12mm、12mm和11mm。当阿莫西林浓度为10µg/mL时,其抑菌带相对较小,分别为16mm、30mm、23mm、22mm和23mm。在BC治疗的动物中,在第3小时发现水肿抑制百分比为67.94%,表明BC在大鼠中具有较高的抗炎活性。结论bc可能有利于降低炎症相关疾病的风险。在将BC推荐用于人类治疗干预之前,还需要进一步的研究。
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Antibacterial and Antiinflammatory Properties of Bovine Colostrum.
CONTEXT Immunity related disorder is one of the leading causes of disease in the world. Oxidative stress and microbial infections play a major role in inflammation-induced diseases. Bovine colostrum (BC) contains immunoglobulins and lactoferrins which help in building the immunity and protect against the bacterial proliferation and growth. AIM This study was designed to investigate the antimicrobial and antiinflammatory activities of BC. MATERIALS AND METHODS Antimicrobial activity was determined by the pour-plate method using five different strains of bacteria (Gram -ve and +ve), and carrageenan-induced rat paw edema method was used for the evaluation of antiinflammatory activity in adult Wistar rats. Diclofenac was used as standard antiinflammatory drug, and amoxicillin was used as standard antimicrobial agent. RESULTS BC showed significant antimicrobial activity against Escherichia. coli, Staphylococcus. aureus, Proteus. vulgaris, Enterobacter. aerogenes and Salmonella. typhi. At 100 µg/mL of BC, the inhibition zones were found to be 13mm, 11mm, 12mm, 12mm, and 11mm, respectively. The BC zones were comparatively smaller than those of amoxicillin at 10µg/mL, where the inhibition zones were 16mm, 30mm, 23mm, 22mm and 23mm, respectively. In the BC treated animals, the percentage edema inhibition was found to be 67.94% at the third hour, suggesting high antiinflammatory activity of BC in rats. CONCLUSION BC may be beneficial in reducing the risks of inflammation associated diseases. Further studies are needed before BC can be recommended for therapeutic interventions in humans.
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来源期刊
CiteScore
3.90
自引率
0.00%
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期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
期刊最新文献
Meet Our Editorial Board Member Diagnosis of Allergic Reactions to Drugs Non-steroidal Anti-inflammatory Drugs Other Antimicrobial Drugs Biologics: Monoclonal Antibodies for Non-cancer Therapy, Cytokines, Fusion Proteins, Enzymes, and Hormones
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