疟疾感染红细胞的外正性阴离子和有机渗透细胞电导率:神话还是现实?

Q3 Computer Science Open Bioinformatics Journal Pub Date : 2011-01-31 DOI:10.2174/1874196701104010003

C. Duranton, Tanneur Valerie, Tauc Michel

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引用次数: 0

摘要

疟疾感染的红细胞获得了新的渗透性通路(NPPs)，以满足红细胞内寄生虫发育对营养和废物处理的需要。人们对npp进行了深入研究，因为它们被认为有兴趣作为疟疾治疗的治疗靶点。在过去的10年里，许多电生理研究已经发现了恶性疟原虫感染红细胞的宿主质膜中新的离子电导(反映了部分NPPs活性)。在本文中，我们回顾了疟疾诱导的向外整流阴离子电导率的电生理/生物物理特性，并将其与文献中描述的其他阴离子电导率和渗透性进行了比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Outward Rectifying Anions and Organic Osmolytes Conductance in Malaria-Infected Erythocytes: Myth or Reality?

Malaria-infected erythrocytes acquired New Permeability Pathways (NPPs) to meet the needs in nutrients and disposal of waste products of the intraerythocytic parasite development. The NPPs have been intensively studied for their putative interest as therapeutic targets for malaria treatment. Over the past 10 years, many electrophysiological studies have identified novel ion conductances (reflecting a part of the NPPs activities) in the host plasma membrane of Plasmodium falciparum-infected erythrocytes. In this article, we review the electrophysiological/biophysical properties of the malaria-induced outwardly rectifying anion conductance and compare this conductance to the other anion conductances and permeabilities already described in the literature.

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来源期刊

Open Bioinformatics Journal Computer Science-Computer Science (miscellaneous)

CiteScore

2.40

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0.00%

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期刊介绍： The Open Bioinformatics Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters, clinical trial studies and guest edited single topic issues in all areas of bioinformatics and computational biology. The coverage includes biomedicine, focusing on large data acquisition, analysis and curation, computational and statistical methods for the modeling and analysis of biological data, and descriptions of new algorithms and databases. The Open Bioinformatics Journal, a peer reviewed journal, is an important and reliable source of current information on the developments in the field. The emphasis will be on publishing quality articles rapidly and freely available worldwide.