{"title":"具有意外生物分布的[11C]PK11195的人类受试者","authors":"A. Roivainen, K. Någren, J. Virta, J. Rinne","doi":"10.2174/1876388X01103010010","DOIUrl":null,"url":null,"abstract":"[N-Methyl11 C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinoline carboxamide [ 11 C]PK11195 is a widely used radiopharmaceutical for in vivo assessment of translocator protein 18 kDa (TSPO) activity using positron emission tomography. Here we present an interesting case of unusual distribution of [ 11 C]PK11195, that is a lack of uptake in tissues known for high expression of the TSPO.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"3 1","pages":"10-11"},"PeriodicalIF":0.0000,"publicationDate":"2011-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Human subject with unexpected biodistribution of [11C]PK11195\",\"authors\":\"A. Roivainen, K. Någren, J. Virta, J. Rinne\",\"doi\":\"10.2174/1876388X01103010010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"[N-Methyl11 C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinoline carboxamide [ 11 C]PK11195 is a widely used radiopharmaceutical for in vivo assessment of translocator protein 18 kDa (TSPO) activity using positron emission tomography. Here we present an interesting case of unusual distribution of [ 11 C]PK11195, that is a lack of uptake in tissues known for high expression of the TSPO.\",\"PeriodicalId\":88754,\"journal\":{\"name\":\"The open nuclear medicine journal\",\"volume\":\"3 1\",\"pages\":\"10-11\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-07-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The open nuclear medicine journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1876388X01103010010\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open nuclear medicine journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1876388X01103010010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
[N-Methyl11 C](R)-1-(2-氯苯基)- n -(1-甲基丙基)-3-异喹啉羧酰胺[11 C]PK11195是一种广泛使用的放射性药物，用于使用正电子发射断层扫描在体内评估转运蛋白18 kDa (TSPO)活性。在这里，我们提出了一个有趣的[11 C]PK11195不寻常分布的案例，即在已知的高表达TSPO的组织中缺乏摄取。
Human subject with unexpected biodistribution of [11C]PK11195
[N-Methyl11 C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinoline carboxamide [ 11 C]PK11195 is a widely used radiopharmaceutical for in vivo assessment of translocator protein 18 kDa (TSPO) activity using positron emission tomography. Here we present an interesting case of unusual distribution of [ 11 C]PK11195, that is a lack of uptake in tissues known for high expression of the TSPO.
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