il-1β(-511 c / t)和il-1β(-31 t / c)基因多态性与急性失代偿性心力衰竭伴低射血分数患者内质网应激标志物水平的关系

4区 农林科学 Q3 Agricultural and Biological Sciences Genetika-Belgrade Pub Date : 2022-01-01 DOI:10.2298/gensr2201329s
Ramazan Sabırlı, Aylin Köseler, E. Mete, İbrahim Türkçüer
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引用次数: 0

摘要

炎症过程在心力衰竭的发病机制中起重要作用。未折叠蛋白在内质网腔内的积累和未折叠蛋白反应信号通路被激活。il - 1 ?基因位于2号染色体上。q14地区。-31和-511单核苷酸多态性(snp)在IL-1?启动子区域。这两个snp影响il -1的表达。本研究旨在探讨IL-1?(- 511c / T)和IL-1?(-31 T / C)基因多态性及内质网应激标志物与炎症标志物的关系。向急诊科申请急性失代偿性心力衰竭的患者。il -1的多态性位点基因序列测定。在所有的研究中,IL-1?(-31 T / C) T等位基因的血清PERK、GRP-78、CHOP和CRP水平中位数高于IL-1?(-31 T/C) C等位基因(p = 0.0001, p = 0.002, p = 0.002, p =0.011)。HF组血清ERK和GRP-78值在IL-1?(-31 T / C) T等位基因与C等位基因个体相比(p = 0.0001和p = 0.006)。对照组血清CHOP水平与IL-1?(-511 C / T) T等位基因与HF组携带C等位基因个体的差异(p = 0.002)。综上所述,我们认为IL-1?(-31 T / C)基因多态性增加,内质网应激反应增加,IL-1?(-31 T / C) T / T基因型或T等位基因。
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Association of il-1β(-511 c / t) and il-1β (-31 t / c) gene polymorphism with endoplasmic reticulum stress marker levels in acute decompensated heart failure with low ejection fraction
Inflammatory processes play an important role in the pathogenesis of heart failure. The accumulation of unfolded proteins in the endoplasmic reticulum lumen and the unfolded protein response signal path is activated. The IL-1? gene is located in the Chromosome 2.q14 region. -31 and -511 single nucleotide polymorphisms (SNPs) were detected in the IL-1?promoter region. These two SNPs affect IL-1expression. This study aims to investigate the presence of IL-1?(-511 C / T) and IL-1? (-31 T / C) gene polymorphisms and the relationship between ER stress markers and inflammatory markers. Patients who applied to the department of emergency medicine with the findings of acute decompensated heart failure. Polymorphic sites of theIL-1? gene were determined by DNA sequencing. In all study, individuals with IL-1?(-31 T / C) T allele have higher serum PERK, GRP-78, CHOP and CRP levels median values than individuals with IL-1?(-31 T/C) C allele (p = 0.0001, p = 0.002, p = 0.002 and p =0.011, respectively). Serum ERK and GRP-78 values in HF group were higher in individuals with IL-1?(-31 T / C) T allele compared to individuals with C allele (p = 0.0001 and p = 0.006). There was a statistically significant difference in serum CHOP levels in the control group with the IL-1? (-511 C / T) T allele and the individuals with the C allele in the HF group (p = 0.002). In conclusion, we consider that the inflammatory response caused by IL-1? (-31 T / C) gene polymorphism increased and the ER stress response increased, inflammatory pathway and ER stress of having IL-1?(-31 T / C) T / T genotype or T allele.
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来源期刊
Genetika-Belgrade
Genetika-Belgrade AGRONOMY-GENETICS & HEREDITY
CiteScore
1.80
自引率
0.00%
发文量
1
审稿时长
6-12 weeks
期刊介绍: The GENETIKA is dedicated to genetic studies of all organisms including genetics of microorganisms, plant genetics, animal genetics, human genetics, molecular genetics, genomics, functional genomics, plant and animal breeding, population and evolutionary genetics, mutagenesis and genotoxicology and biotechnology.
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