老年人使用苯二氮卓类药物的负面影响:简要回顾

Claudio Rojas-Jara
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摘要

多药疗法的一部分与老年患者随年龄增长而出现的不同医疗状况有关。无论处方是否充分,大多数药物化合物都可能对消费者产生负面影响。老年人最常用的精神药物之一是苯二氮卓类药物。这种药物通常用于治疗失眠或焦虑,据说对患者的健康有潜在风险。目的:确定老年人苯二氮卓类药物不良反应是否存在科学依据。方法:系统查阅2007 ~ 2017年发表的科学文献。数据库为Scielo、Pubmed、Redalyc、Ebscohost和谷歌Scholar。搜索关键词包括老年人、苯二氮卓类药物、生理和心理影响、精神药物,英文和西班牙文均有。研究结果:老年人消耗最多的苯二氮卓类药物是地西泮。焦虑和失眠是服用这种药物最常见的原因。至于负面影响,这种药很容易上瘾。副作用包括摔倒的可能性很高,导致骨折,认知能力下降,以及最初处方的症状矛盾地增加。服用苯二氮卓类药物的老年人多为女性。
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Efectos negativos del uso de benzodiacepinas en adultos mayores: Una breve revisión
Introduction: One part of polypharmacy is related to different medical conditions that come with age in senior patients. Whether they are adequately prescribed or not, most pharmaceutical compounds may potentially produce negative effects in consumers. One of the most highly prescribed psychopharmaceutics in seniors is benzodiazepine. This drug, usually prescribed to treat insomnia or anxiety, is said to be potentially risky for patients’ health. Objective: To determine the existence of scientific evidence of benzodiazepine negative effects in seniors. Method: Scientific publications from 2007 through to 2017 were systematic ally consulted. The database was Scielo, Pubmed, Redalyc, Ebscohost, and Google Scholar.  Keywords for the search included seniors, benzodiazepines, physical and psychological effects, psychopharmaceutics, both in English and Spanish. Findings: The most hig hly consumed benzodiazepine by seniors is Diazepam. Anxiety and insomnia are among the most frequent reasons for its prescription. Regarding negative effects, this drug is highly addictive. Side effects include a high probability of falling, leaving bone fractures as a result, decline of cognitive abilities, and a paradoxical increase of the symptoms for which it was originally prescribed. Senior consumers of benzodiazepine are more frequently female.
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