纳米二氧化硅MCM48:Eu3+在小鼠脑内系统给药的设计与评价

IF 1.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI:10.21577/0103-5053.20230056
L. Azevedo, B. Andrade-da-Costa, R. Augusto, L. Luz, I. de Souza, Licarion Pinto, I. Alves, S. Alves Júnior
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引用次数: 0

摘要

在本研究中,我们测试了概念的证明,即移动介孔二氧化硅纳米颗粒组合物(MCM) No. 48掺杂三价铕(nanoMCM48:Eu3+),可以作为一种合适的载体,将神经细胞输送到健康成年瑞士小鼠的大脑,而不会造成组织损伤。此外,我们还测试了该纳米颗粒在体外释放分子的能力,将pH值为7.4的磷酸盐缓冲溶液中的咖啡因或尼古丁作为药物模型,以适应大脑细胞内和细胞外介质。咖啡因和尼古丁吸附的纳米颗粒(CAF@MCM48:Eu3+和NIC@MCM48:Eu3+)在大脑皮层实质中被观察到,并在细胞质中弥散分布。使用多元伴侣识别方法的统计分析表明,没有细胞损伤的迹象,因为它的特征是染色质凝聚,核凝聚或碎裂。分析了纳米omcm48:Eu3+的粒径、发光性能和活性成分的释放特性。在大脑皮层实质中观察到CAF@MCM48:Eu3+和NIC@MCM48:Eu3+纳米颗粒,并在细胞质中弥散分布,并分析其活性成分的释放情况。因此,研究表明,通过静脉组织给药的介孔二氧化硅纳米颗粒可以作为健康小鼠大脑中神经细胞的合适载体,而不会造成损伤。
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Design and Evaluation of Systemic Administration of Nano Silica MCM48:Eu3+ in Mouse Brain
In the present study, we tested the proof of concept that mobil mesoporous silica nanoparticle composition of matter (MCM) No. 48 doped with trivalent europium (nanoMCM48:Eu3+) administered systemically intravenously can act as a suitable vehicle to deliver neural cells to the brain of healthy adult Swiss mice without causing tissue damage. Moreover, we also tested the ability of this nanoparticle to release molecules in vitro, using as drug models caffeine or nicotine in phosphate buffer solution with pH 7.4 adequate to intra and extra-celular medium of the brain. The caffeine and nicotine adsorbed nanoparticles (CAF@MCM48:Eu3+ and NIC@MCM48:Eu3+) were observed in the parenchyma of the cerebral cortex and diffusely dispersed in the cellular cytoplasm. Statistical analysis using multivariate partner recognition methods indicated that there was no sign of cell damage, as it was characterized by chromatin condensation, nuclear condensation, or fragmentation. The characterization of nanoMCM48:Eu3+ as particle size, luminescent properties and release of active components were analyzed. The CAF@MCM48:Eu3+ and NIC@MCM48:Eu3+ nanoparticles were observed in the cerebral cortex parenchyma and diffusely dispersed in the cell cytoplasm, and the release of active components was analyzed. Therefore, the studies showed that mesoporous silica nanoparticles administered systemically via intravenous tissue can act as a suitable vehicle for neural cells in the brain of healthy mice without causing damage.
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来源期刊
CiteScore
2.90
自引率
7.10%
发文量
99
审稿时长
3.4 months
期刊介绍: The Journal of the Brazilian Chemical Society embraces all aspects of chemistry except education, philosophy and history of chemistry. It is a medium for reporting selected original and significant contributions to new chemical knowledge.
期刊最新文献
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