J. Harnoss, Moritz J. Strowitzki, P. Radhakrishnan, L. K. Platzer, J. Harnoss, T. Hank, Jun Cai, A. Ulrich, Martin Schneider
{"title":"手术中含有脯氨酰羟化酶结构域的酶的治疗抑制:推测的应用和挑战","authors":"J. Harnoss, Moritz J. Strowitzki, P. Radhakrishnan, L. K. Platzer, J. Harnoss, T. Hank, Jun Cai, A. Ulrich, Martin Schneider","doi":"10.2147/HP.S60872","DOIUrl":null,"url":null,"abstract":"Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged ischemia and inflammation, and are promising targets for therapeutic intervention. This review focuses on aspects of therapeutic PHD modulation in surgically relevant disease conditions such as hepatic and intestinal disorders, wound healing, innate immune responses, and tumorigenesis, and discusses the therapeutic potential and challenges of PHD inhibition in surgical patients.","PeriodicalId":73270,"journal":{"name":"Hypoxia (Auckland, N.Z.)","volume":"3 1","pages":"1 - 14"},"PeriodicalIF":0.0000,"publicationDate":"2015-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/HP.S60872","citationCount":"26","resultStr":"{\"title\":\"Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges\",\"authors\":\"J. Harnoss, Moritz J. Strowitzki, P. Radhakrishnan, L. K. Platzer, J. Harnoss, T. Hank, Jun Cai, A. Ulrich, Martin Schneider\",\"doi\":\"10.2147/HP.S60872\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged ischemia and inflammation, and are promising targets for therapeutic intervention. This review focuses on aspects of therapeutic PHD modulation in surgically relevant disease conditions such as hepatic and intestinal disorders, wound healing, innate immune responses, and tumorigenesis, and discusses the therapeutic potential and challenges of PHD inhibition in surgical patients.\",\"PeriodicalId\":73270,\"journal\":{\"name\":\"Hypoxia (Auckland, N.Z.)\",\"volume\":\"3 1\",\"pages\":\"1 - 14\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-01-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2147/HP.S60872\",\"citationCount\":\"26\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hypoxia (Auckland, N.Z.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/HP.S60872\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hypoxia (Auckland, N.Z.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/HP.S60872","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged ischemia and inflammation, and are promising targets for therapeutic intervention. This review focuses on aspects of therapeutic PHD modulation in surgically relevant disease conditions such as hepatic and intestinal disorders, wound healing, innate immune responses, and tumorigenesis, and discusses the therapeutic potential and challenges of PHD inhibition in surgical patients.