纳米姜黄素对小鼠辐射致死的防护作用

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY Nanomedicine Journal Pub Date : 2019-01-01 DOI:10.22038/NMJ.2019.06.006
R. Sadeghi, A. Razzaghdoust, Mohsen Bakhshandeh, F. Nasirinezhad, B. Mofid
{"title":"纳米姜黄素对小鼠辐射致死的防护作用","authors":"R. Sadeghi, A. Razzaghdoust, Mohsen Bakhshandeh, F. Nasirinezhad, B. Mofid","doi":"10.22038/NMJ.2019.06.006","DOIUrl":null,"url":null,"abstract":"Objective(s): Curcumin, a natural plant product, is commonly known as wonder drug of life, but the poor bioavailability of its free form has hindered its clinical development. The aim of the present study was to investigate the radioprotective effect of nanocurcumin on survival of mice under whole body X-ray irradiation. Materials and Methods: The Naval Medical Research Institute (NMRI) mice randomly assigned to separate groups and received nanocurcumin via oral gavage at different time points related to irradiation. The survival of mice was evaluated daily for 30 days post-irradiation and finally, the LD50/30 was calculated using Probit analysis. The 30-day survival curve was plotted using the Kaplan-Meier survival curve and the median survival of different subgroups was compared using log-rank test. The P-values less than 0.05 were considered significant. Results: Our results showed that the administration of oral nanocurcumin could effectively reduce the mortality rate in the irradiated mice. Five days pretreatment with nanocurcumin (4 mg/kg/day) induced maximum radioprotective effect. The LD50/30 was 7.18 Gray (Gy) (95% confidence interval [CI]: 6.59-7.77) and 8.78 Gy (95% CI: 8.14-9.50) for irradiation-only and the optimum nanocurcumin group (pre-irradiation group), respectively (dose reduction factor [DRF] = 1.22). Continued administration of nanocurcumin up to seven days post-irradiation resulted in no further radioprotection. Conclusions: The results obtained in this study confirmed the efficacy of nanocurcumin as a radioprotective agent against radiation-induced mortality in mice. The specific characteristics of nanocurcumin, such as non-toxicity, edibility, availability, make this phytochemical as a potential radioprotective agent in the radiotherapy setting and radiation accidents. Further clinical studies are highly recommended.","PeriodicalId":18933,"journal":{"name":"Nanomedicine Journal","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Nanocurcumin as a radioprotective agent against radiation-induced mortality in mice\",\"authors\":\"R. Sadeghi, A. Razzaghdoust, Mohsen Bakhshandeh, F. Nasirinezhad, B. Mofid\",\"doi\":\"10.22038/NMJ.2019.06.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective(s): Curcumin, a natural plant product, is commonly known as wonder drug of life, but the poor bioavailability of its free form has hindered its clinical development. The aim of the present study was to investigate the radioprotective effect of nanocurcumin on survival of mice under whole body X-ray irradiation. Materials and Methods: The Naval Medical Research Institute (NMRI) mice randomly assigned to separate groups and received nanocurcumin via oral gavage at different time points related to irradiation. The survival of mice was evaluated daily for 30 days post-irradiation and finally, the LD50/30 was calculated using Probit analysis. The 30-day survival curve was plotted using the Kaplan-Meier survival curve and the median survival of different subgroups was compared using log-rank test. The P-values less than 0.05 were considered significant. Results: Our results showed that the administration of oral nanocurcumin could effectively reduce the mortality rate in the irradiated mice. Five days pretreatment with nanocurcumin (4 mg/kg/day) induced maximum radioprotective effect. The LD50/30 was 7.18 Gray (Gy) (95% confidence interval [CI]: 6.59-7.77) and 8.78 Gy (95% CI: 8.14-9.50) for irradiation-only and the optimum nanocurcumin group (pre-irradiation group), respectively (dose reduction factor [DRF] = 1.22). Continued administration of nanocurcumin up to seven days post-irradiation resulted in no further radioprotection. Conclusions: The results obtained in this study confirmed the efficacy of nanocurcumin as a radioprotective agent against radiation-induced mortality in mice. The specific characteristics of nanocurcumin, such as non-toxicity, edibility, availability, make this phytochemical as a potential radioprotective agent in the radiotherapy setting and radiation accidents. Further clinical studies are highly recommended.\",\"PeriodicalId\":18933,\"journal\":{\"name\":\"Nanomedicine Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomedicine Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22038/NMJ.2019.06.006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NANOSCIENCE & NANOTECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/NMJ.2019.06.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NANOSCIENCE & NANOTECHNOLOGY","Score":null,"Total":0}
引用次数: 5

摘要

目的:姜黄素是一种天然植物产物,被称为生命的神奇药物,但其游离形态的生物利用度较差,阻碍了其临床开发。本研究旨在探讨纳米姜黄素对全身x射线照射小鼠的辐射防护作用。材料与方法:将美国海军医学研究所(Naval Medical Research Institute, NMRI)小鼠随机分为两组,在辐照相关的不同时间点灌胃纳米姜黄素。照射后30天,每天评估小鼠的存活率,最后采用Probit分析法计算LD50/30。30天生存曲线采用Kaplan-Meier生存曲线绘制,不同亚组的中位生存比较采用log-rank检验。p值小于0.05为显著性。结果:口服纳米姜黄素能有效降低辐照小鼠的死亡率。纳米姜黄素预处理5 d (4 mg/kg/d),辐射防护效果最大。仅辐照组和最佳纳米姜黄素组(辐照前组)的LD50/30分别为7.18 Gy(95%可信区间[CI]: 6.59-7.77)和8.78 Gy (95% CI: 8.14-9.50)(剂量减少因子[DRF] = 1.22)。辐照后持续给予纳米姜黄素达7天,没有进一步的辐射保护。结论:本研究结果证实了纳米姜黄素对小鼠辐射致死性的防护作用。纳米姜黄素的无毒性、可食性、可获得性等特性使其成为放射治疗和辐射事故中潜在的辐射防护剂。强烈建议进一步的临床研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Nanocurcumin as a radioprotective agent against radiation-induced mortality in mice
Objective(s): Curcumin, a natural plant product, is commonly known as wonder drug of life, but the poor bioavailability of its free form has hindered its clinical development. The aim of the present study was to investigate the radioprotective effect of nanocurcumin on survival of mice under whole body X-ray irradiation. Materials and Methods: The Naval Medical Research Institute (NMRI) mice randomly assigned to separate groups and received nanocurcumin via oral gavage at different time points related to irradiation. The survival of mice was evaluated daily for 30 days post-irradiation and finally, the LD50/30 was calculated using Probit analysis. The 30-day survival curve was plotted using the Kaplan-Meier survival curve and the median survival of different subgroups was compared using log-rank test. The P-values less than 0.05 were considered significant. Results: Our results showed that the administration of oral nanocurcumin could effectively reduce the mortality rate in the irradiated mice. Five days pretreatment with nanocurcumin (4 mg/kg/day) induced maximum radioprotective effect. The LD50/30 was 7.18 Gray (Gy) (95% confidence interval [CI]: 6.59-7.77) and 8.78 Gy (95% CI: 8.14-9.50) for irradiation-only and the optimum nanocurcumin group (pre-irradiation group), respectively (dose reduction factor [DRF] = 1.22). Continued administration of nanocurcumin up to seven days post-irradiation resulted in no further radioprotection. Conclusions: The results obtained in this study confirmed the efficacy of nanocurcumin as a radioprotective agent against radiation-induced mortality in mice. The specific characteristics of nanocurcumin, such as non-toxicity, edibility, availability, make this phytochemical as a potential radioprotective agent in the radiotherapy setting and radiation accidents. Further clinical studies are highly recommended.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
自引率
0.00%
发文量
0
审稿时长
12 weeks
期刊最新文献
Nano aptasensors for detection of streptomycin: A review Synthesis of silver nanoparticles by Galega officinalis and its hypoglycemic effects in type 1 diabetic rats Evaluation of mPEG-PLA nanoparticles as vaccine delivery system for modified protective antigen of Bacillus anthracis Synthesis and evaluation of SPION@CMD@Ser-LTVSPWY peptide as a targeted probe for detection of HER2+ cancer cells in MRI Synthesis of L-DOPA conjugated doxorubicin-polyethylenimine nanocarrier and evaluation of its cytotoxicity on A375 and HepG2 cell lines
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1