Michał Wrzecionek, J. Howis, Paweł Ruśkowski, Agnieszka Gadomska‐Gajadhur
{"title":"用单纯形法优化合成PGSu的条件","authors":"Michał Wrzecionek, J. Howis, Paweł Ruśkowski, Agnieszka Gadomska‐Gajadhur","doi":"10.24425/CPE.2020.132535","DOIUrl":null,"url":null,"abstract":"Poly(glycerol succinate) – PGSu – is one of glycerol polyesters which has focused nowadays the interest of scientists developing new biomaterials. Probably the polyester could be used as a drug carrier or as a cell scaffold in tissue engineering. Due to its potential use in medicine, it is extremely important to develop a synthesis and then optimize it to obtain a material with desired properties. In this work one flask two-step polycondensation of glycerol and succinic anhydride to PGSu is presented. Synthesis was optimized with the simplex method and also described using a second-degree equation with two variables (temperature and time) to better find the optimum conditions. PGSu was characterized by FTIR spectroscopy, NMR spectroscopy, degree of esterification was determined, and also molecular weight was calculated for each experiment using Carothers equation. A new synthesis route was developed and optimized. Temperature and time influence on molecular weight and esterification degree of obtained polyester are presented. Based on experiments conducted in this work, it was possible to obtain poly(glycerol succinate) with molecular weight of 6.7 kDa.","PeriodicalId":55267,"journal":{"name":"Chemical and Process Engineering-Inzynieria Chemiczna I Procesowa","volume":"1 1","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Optimizing the conditions of PGSu synthesiswith simplex method\",\"authors\":\"Michał Wrzecionek, J. Howis, Paweł Ruśkowski, Agnieszka Gadomska‐Gajadhur\",\"doi\":\"10.24425/CPE.2020.132535\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Poly(glycerol succinate) – PGSu – is one of glycerol polyesters which has focused nowadays the interest of scientists developing new biomaterials. Probably the polyester could be used as a drug carrier or as a cell scaffold in tissue engineering. Due to its potential use in medicine, it is extremely important to develop a synthesis and then optimize it to obtain a material with desired properties. In this work one flask two-step polycondensation of glycerol and succinic anhydride to PGSu is presented. Synthesis was optimized with the simplex method and also described using a second-degree equation with two variables (temperature and time) to better find the optimum conditions. PGSu was characterized by FTIR spectroscopy, NMR spectroscopy, degree of esterification was determined, and also molecular weight was calculated for each experiment using Carothers equation. A new synthesis route was developed and optimized. Temperature and time influence on molecular weight and esterification degree of obtained polyester are presented. Based on experiments conducted in this work, it was possible to obtain poly(glycerol succinate) with molecular weight of 6.7 kDa.\",\"PeriodicalId\":55267,\"journal\":{\"name\":\"Chemical and Process Engineering-Inzynieria Chemiczna I Procesowa\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2023-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical and Process Engineering-Inzynieria Chemiczna I Procesowa\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.24425/CPE.2020.132535\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical and Process Engineering-Inzynieria Chemiczna I Procesowa","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.24425/CPE.2020.132535","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
Optimizing the conditions of PGSu synthesiswith simplex method
Poly(glycerol succinate) – PGSu – is one of glycerol polyesters which has focused nowadays the interest of scientists developing new biomaterials. Probably the polyester could be used as a drug carrier or as a cell scaffold in tissue engineering. Due to its potential use in medicine, it is extremely important to develop a synthesis and then optimize it to obtain a material with desired properties. In this work one flask two-step polycondensation of glycerol and succinic anhydride to PGSu is presented. Synthesis was optimized with the simplex method and also described using a second-degree equation with two variables (temperature and time) to better find the optimum conditions. PGSu was characterized by FTIR spectroscopy, NMR spectroscopy, degree of esterification was determined, and also molecular weight was calculated for each experiment using Carothers equation. A new synthesis route was developed and optimized. Temperature and time influence on molecular weight and esterification degree of obtained polyester are presented. Based on experiments conducted in this work, it was possible to obtain poly(glycerol succinate) with molecular weight of 6.7 kDa.
期刊介绍：
The content, aim and scope of the proposals should comply with the main subject of the journal, i.e. they should deal with mathematical modelling and/or experimental investigations on momentum, heat and mass transfer, unit processes and operations, integrated processes, biochemical engineering, statics and kinetics of chemical reactions. The experiments and modelling may cover different scales and processes ranging from the molecular phenomena up to production systems. The journal language is grammatically correct British English.
Chemical and Process Engineering publishes: i) full text research articles, ii) invited reviews, iii) letters to the editor and iv) short communications, aiming at important new results and/or applications. Each of the publication form is peer-reviewed by at least two independent referees.
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