KDM4C通过上调JAG1基因表达促进多发性骨髓瘤细胞增殖和迁移

IF 0.3 4区 医学 Q4 ENGINEERING, BIOMEDICAL Journal of Hard Tissue Biology Pub Date : 2021-01-01 DOI:10.2485/jhtb.30.257
Dan Yu, Min Hu, Qiang Tian
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引用次数: 0

摘要

多发性骨髓瘤是一种常见的血液系统恶性肿瘤。尽管在治疗策略方面取得了进展,但多发性骨髓瘤的预后远不能令人满意。因此,研究多发性骨髓瘤进展的确切机制势在必行。赖氨酸去甲基化酶4C (KDM4C)被证明是癌症的重要调节因子,但其对多发性骨髓瘤的作用尚不清楚。因此,我们旨在研究KDM4C对多发性骨髓瘤进展的影响,并探讨其确切的作用机制。本研究纳入70例多发性骨髓瘤患者和45例正常供体(志愿者)。结果显示,70例多发性骨髓瘤患者血浆及多发性骨髓瘤细胞中高表达KDM4C。敲低KDM4C可抑制多发性骨髓瘤细胞的增殖和迁移。此外,JAG1在70例骨髓瘤患者及多发性骨髓瘤细胞的血浆中表达增强。JAG1表达与KDM4C表达呈正相关。此外,KDM4C敲低可抑制多发性骨髓瘤中Notch信号蛋白Notch-1、NICD-1和Hes-1。KDM4C敲低通过下调JAG1的表达抑制多发性骨髓瘤细胞的增殖和迁移。总的来说,KDM4C通过上调JAG1基因表达促进多发性骨髓瘤细胞的增殖和迁移。KDM4C可能是多发性骨髓瘤治疗的一个有希望的靶点。并将siRNA共转染到多发性骨髓瘤细胞中。结果表明,JAG1对多发性骨髓瘤细胞增殖的抑制作用明显减弱,但对骨髓瘤细胞增殖的抑制作用明显减弱
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KDM4C Promotes Proliferation and Migration of Multiple Myeloma Cells by Up-Regulating JAG1 Gene Expression
: Multiple myeloma is a frequent hematological malignancy. Although progress has been made in therapeutic strat-egies, the prognosis of multiple myeloma is far from satisfactory. Therefore, it is imperative to investigate the precise mechanism of multiple myeloma progression. Lysine Demethylase 4C (KDM4C) was demonstrated to be a vital regulator in cancers, while its action on multiple myeloma remains elusive. Thus, we aimed to investigate the effect of KDM4C on multiple myeloma progression and explored the precise mechanism of action. In this study, 70 multiple myeloma patients and 45 normal donors (volunteers) were enrolled. Results showed that KDM4C was highly expressed in plasma of 70 multiple myeloma patients and multiple myeloma cells. Knockdown of KDM4C suppressed proliferation and migration of multiple myeloma cells. Besides, JAG1 expression was enhanced in plasma of 70 myeloma patients and multiple myeloma cells. JAG1 expression was positively correlated with KDM4C expression. Furthermore, KDM4C knockdown suppressed Notch signaling proteins Notch-1, NICD-1, and Hes-1 in multiple myeloma. Moreover, KDM4C knockdown suppressed the proliferation and migration of multiple myeloma cells through down-regulating JAG1 expression. Collectively, KDM4C promotes the proliferation and migration of multiple myeloma cells by up-regulating JAG1 gene expression. KDM4C may be a promising target for multiple myeloma therapy. regulation aggressive behav iors studied and siRNA against co-transfected into multiple myeloma cells. revealed knockdown of ability but abrogated The effect of JAG1 on multiple myeloma cell prolifera and
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来源期刊
Journal of Hard Tissue Biology
Journal of Hard Tissue Biology ENGINEERING, BIOMEDICAL-
CiteScore
0.90
自引率
0.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Information not localized
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