Utility of a Novel Clinical Triad (Chandrans TRIAD) for Early Diagnosis of Autoimmune Encephalitis (AIE) in Patients with Progressive Cognitive Decline

Autoimmune Encephalitis (AIE) often presents with cognitive and behavioural symptoms often mimickingprogressive degenerative dementias. Early identification of these potentially reversible conditions can improve patientoutcomes, reduce caregiver burden and promote cost effectiveness. The clinical trial of symptoms namely panicattacks, catatonia and day time sleepiness is often associated with anti N-methyl D-aspartate (NMDA) receptormediated encephalitis and the former two symptoms along with seizures is suggestive of anti-Voltage Gated PotassiumChannel (VGKC) receptor mediated encephalitis. This triad serves as a pragmatic tool to easily identify AIE and alsohelps to distinguish between the two conditions.