Single-use perfusion bioreactors support continuous biomanufacturing

The field of biomanufacturing employs many single-use (SU) systems for features such as lower initial investment and reduced time-to-market. Continuous manufacturing methods can provide increased product quality and process control, and reduced operating costs. Continuous biomanufacturing (CB) additionally promises reduced classified area extent, personnel requirements and operating steps. The benefits of SU CB include heightened processing parameter consistency and increased process flexibility. Perfusion culture (PC) is supported by many specialized SU and hybrid bioreactors. These and many accessory perfusion-enabling technologies are the main way of implementing upstream CB. Valuable features provided by PC include reduced product reactor-residency and increased reactor-volumetric productivity. SU PC supports the dream of enterprise managed, modular, end-to-end integrated and closed CB providing higher environmental sustainability.