{"title":"泮托拉唑治疗消化性溃疡合并上消化道出血的疗效观察","authors":"Tang-lei Shao","doi":"10.47939/mh.v2i1.104","DOIUrl":null,"url":null,"abstract":"Objective:To evaluate the effect of pantoprazole in the treatment of peptic ulcer. Method:93 patients with active peptic ulcer confirmed by endoscopy were randomly allocated to study group(group A, n=50) and control group (group B, n=43). Pantoprazole was given a dose of 40 mg po at 8 am in group A, and group B received ranitidine 300 mg p.o. at bedtime for 4 weeks. Results:①The mean time of upper abdominal pain regression for group A (4.4 days) was markedly less than that for group B(7.6 days) and the healing rate of ulcer for group A(96.0%) was significantly higher than that for group B(69.8%) with statistical differences (P0.05,P0.01).②In group A and group B, the healing rates of duodenal ulcer were 96.9% and 71.4% respectively, and gastric ulcer were 94.4% and 66.7% respectively. There were significant differences (P0.01,P0.05). Conclusion:Our data show that the effect of pantoprazole in the treatment of peptic ulcer is satisfactory, and gains an advantage over that of ranitidine.","PeriodicalId":12906,"journal":{"name":"医药导报","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Effect of Pantoprazole in the Treatment of Peptic Ulcer Complicated with PUCH (Upper Gastrointestinal Hemorrhage)\",\"authors\":\"Tang-lei Shao\",\"doi\":\"10.47939/mh.v2i1.104\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective:To evaluate the effect of pantoprazole in the treatment of peptic ulcer. Method:93 patients with active peptic ulcer confirmed by endoscopy were randomly allocated to study group(group A, n=50) and control group (group B, n=43). Pantoprazole was given a dose of 40 mg po at 8 am in group A, and group B received ranitidine 300 mg p.o. at bedtime for 4 weeks. Results:①The mean time of upper abdominal pain regression for group A (4.4 days) was markedly less than that for group B(7.6 days) and the healing rate of ulcer for group A(96.0%) was significantly higher than that for group B(69.8%) with statistical differences (P0.05,P0.01).②In group A and group B, the healing rates of duodenal ulcer were 96.9% and 71.4% respectively, and gastric ulcer were 94.4% and 66.7% respectively. There were significant differences (P0.01,P0.05). Conclusion:Our data show that the effect of pantoprazole in the treatment of peptic ulcer is satisfactory, and gains an advantage over that of ranitidine.\",\"PeriodicalId\":12906,\"journal\":{\"name\":\"医药导报\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"医药导报\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.47939/mh.v2i1.104\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"医药导报","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.47939/mh.v2i1.104","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Pantoprazole in the Treatment of Peptic Ulcer Complicated with PUCH (Upper Gastrointestinal Hemorrhage)
Objective:To evaluate the effect of pantoprazole in the treatment of peptic ulcer. Method:93 patients with active peptic ulcer confirmed by endoscopy were randomly allocated to study group(group A, n=50) and control group (group B, n=43). Pantoprazole was given a dose of 40 mg po at 8 am in group A, and group B received ranitidine 300 mg p.o. at bedtime for 4 weeks. Results:①The mean time of upper abdominal pain regression for group A (4.4 days) was markedly less than that for group B(7.6 days) and the healing rate of ulcer for group A(96.0%) was significantly higher than that for group B(69.8%) with statistical differences (P0.05,P0.01).②In group A and group B, the healing rates of duodenal ulcer were 96.9% and 71.4% respectively, and gastric ulcer were 94.4% and 66.7% respectively. There were significant differences (P0.01,P0.05). Conclusion:Our data show that the effect of pantoprazole in the treatment of peptic ulcer is satisfactory, and gains an advantage over that of ranitidine.
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Herald of Medicine Magazine is a professional journal of medicine for domestic and foreign public circulation approved by the Press and Publication Bureau of the Propaganda Department of the Central Committee of the Communist Party of China (CPC), founded in 1982 and published monthly on the 1st of each month under the supervision of the Hubei Provincial Drug Administration and sponsored by Tongji Hospital attached to the Tongji Medical College of Huazhong University of Science and Technology and the Chinese Society of Pharmacology.
Herald of Medicine is a source journal of China Science and Technology Paper Statistics of the Ministry of Science and Technology of China (i.e., China Science and Technology Core Journal), and a selected journal of Chinese Core Journals in the General List of Chinese Core Journals of Peking University Library (i.e., Chinese Core Journals). It is included in Chinese databases such as Wanfang Data Source Systematic Journal Group, China Academic Journal Comprehensive Evaluation Database, Chinese Science and Technology Journal Database, China Biomedical Journal Citation Database, and Superstar Domain Publishing. It is included in WHO Western Pacific Region Medical Index (WPRIM), Japan Science and Technology Agency Database (JST), American Chemical Abstracts (CA), International Pharmaceutical Abstracts (IPA), and Ulrich Periodicals Directory (UPD). 2020-2022, it will be listed in the World Journal Clout Index (WJCI) Report (Science and Technology) for consecutive years. Recognized by the state as a promotional media for publishing prescription drug advertisements.
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