在COVID-19诊断和医疗建议的背景下假阳性(结果)的概念

E. Stoczyńska-Fidelus, P. Rieske
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引用次数: 0

摘要

COVID-19就是诊断面临巨大挑战的一个例子。在许多疾病和综合征的情况下,有可能重复检测,分配用于诊断的时间甚至以周计算,而不是像COVID-19那样以小时计算。因此,与COVID-19相关的局势导致诊断医生和患者之间存在大量紧张关系。特别是在这种情况下,根据积极的结果,不仅要决定选择可能的治疗方法,还要决定隔离。本文介绍了用于COVID-19诊断的检测(主要是RT-PCR)的预测价值,重点介绍了假阳性结果的概念。这篇文章表明,这是一个相对的术语,取决于所提出的问题、诊断的目的(选择治疗方法、隔离决定、疾病检测),甚至是SARS-CoV-2病毒的变体。有效的COVID-19疫苗接种,康复患者比例的增加,以及SARS-CoV-2组粒变体的出现,使所有这些问题最小化。然而,放弃广泛使用的筛查检测不应导致完全放弃COVID-19检测。部分人群可能仍然会死于这种疾病,有效的靶向治疗已经存在。为了使这种疗法个性化,必须使用RT-PCR等测试。
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The concept of a false-positive (result) in the context of COVID-19 diagnostics and medical recommendations
COVID-19 is an example of a big challenge for diagnostics. In the case of many diseases and syndromes, there is a possibility to repeat the tests, and the time allocated for diagnosis is counted even in weeks, not in hours, as in COVID-19. The situation related to COVID-19, therefore leads to a large number of tensions, both among diagnostic physicians and patients. Especially that in this case, based on a positive result, the decision is being made not only about the choice of a possible therapy, but also about quarantine. This article refers to the predictive value of tests used in the diagnosis of COVID-19 (mainly RT-PCR), focusing on the concept of a false positive result. The article demonstrates that this is a relative term, depending on the question posed, the purpose of the diagnosis (selection of therapy, quarantine decision, disease detection), or even the variant of the SARS-CoV-2 virus. Effective vaccination against COVID-19, the increasing percentage of convalescent patients, and the emergence of the SARS-CoV-2 omicron variant minimalize all these problems. However, shifting away from widely used screening tests, should not cause abandoning COVID-19 testing completely. Part of the population may still die from the disease and effective targeted therapy already exists. In order to personalize this therapy, a test such as RT-PCR must be used.
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来源期刊
自引率
50.00%
发文量
18
期刊介绍: Alergologia Polska - Polish Journal of Allergology is aimed mainly at allergologists, but also medical doctors working in related fields, such as otolaryngology, pulmonology, and dermatology. The main goal of the journal is to ensure rapid publication of important research papers and interesting case studies from the following areas: allergology, diagnostics, therapy of allergic diseases, in particular in the area of immunotherapy, rhinitis, asthma. The Editorial Board accepts for publication original papers, case studies and letters to the Editor. We also publish review articles (both commissioned and those agreed upon with the Editor-in-Chief), articles dealing with standards of medical practice, as well as special issues. The journal is published quarterly. We guarantee short review times (up to two weeks) and immediate publication on-line upon Editor acceptance.
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