摩洛哥结核分子流行病学及结核分枝杆菌复合体传播动力学

I. Chaoui, A. Oudghiri, Mzibri Mei
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引用次数: 2

摘要

本综述根据许多国家研究分析了1997年以来摩洛哥的结核病流行病学情况;通过应用IS6110RFLP、spoligotyping和MIRUs-VNTR等遗传方法,研究MTB群体结构,目的是呈现摩洛哥MTB遗传景观和结核病在人群中的传播动态。总体而言,摩洛哥的MTBC种群结构几乎是无性系,高度同质和稳定的。重要的是,必须建立一个前瞻性的基因分型规划,以便更好地评估摩洛哥结核病的感染和传播途径。
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Molecular Epidemiology of Tuberculosis and Transmission Dynamics of Mycobacterium tuberculosis Complex in Morocco
The present review draw a picture of the epidemiology of tuberculosis in Morocco since 1997 based on many national studies that have analysed; MTB population structure, by applying genetic approaches such as IS6110RFLP, spoligotyping and MIRUs-VNTR, with the goal of presenting the MTB genetic landscape in Morocco and the transmission dynamics of TB within the population. Overall, MTBC population structure in Morocco is almost clonal, highly homogeneous and stable. Importantly, a prospective genotyping program has to be set up to better evaluate the routes of infection and transmission of TB in Morocco.
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