泰国安达曼海海绵提取物的生物活性研究

Q3 Agricultural and Biological Sciences Eurasian Journal of Biosciences Pub Date : 2010-07-01 DOI:10.5053/EJOBIOS.2010.4.0.8
Patchara Pedpradab, Wanlapa Molex, V. Nukoolkarn, Udomsak Darumas
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引用次数: 8

摘要

从泰国安达曼海采集的18种海绵中提取了36种有机提取物。对其抗疟疾、抗结核、抗单纯疱疹病毒、抗菌、抗乙酰胆碱酯酶和细胞毒活性进行了检测。4个提取物均有抗m。结核、1种抗疟疾、24种抗菌和1种提取物具有细胞毒活性。然而,抗乙酰胆碱酯酶和抗1型单纯疱疹病毒(HSV-1)活性未见记录。从青花、软毛和网状软骨病中提取的二氯甲烷提取物显示出潜在的抗m。MIC分别为50、100和200 mg/mL。通风Phakellia ventilabum提取物的己烷部分具有抗疟活性(MIC= 2.8 mg/mL),二氯甲烷部分具有抗疟活性。mc200和IC50分别为7.1 mg/mL。在提取物的己烷和二氯甲烷部分都发现了抗菌活性。
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Biological activities of extracts from Andaman Sea sponges, Thailand
Thirty six organic extracts were prepared from eighteen marine sponges collected from the Andaman Sea, Thailand. The extracts were examined for anti-malaria, anti-Microbacterium tuberculosis, anti-herpes simplex virus, antimicrobial, anti-acetylcholinesterase enzyme and cytotoxic activities. Four extracts showed anti-M. tuberculosis, one anti-malarial, twenty four antimicrobial and one extract exhibited cytotoxic activity. However, anti-acetylcholinesterase enzyme and anti-herpes simplex virus type 1 (HSV-1) activities were not recorded. Dichloromethane extracts prepared from Axinyssa sp., Halichondria sp. and Chondrosia reticulata exhibited potential anti-M. tuberculosis at MIC 50, 100 and 200 mg/mL, respectively. The Hexane part of Phakellia ventilabrum extract showed anti-malarial activity (MIC= 2.8 mg/mL) while the dichloromethane extract showed anti-M. tuberculosis and cytotoxic activity with MIC 200 and IC50 7.1 mg/mL, respectively. Antimicrobial activity was found in both the hexane and dichloromethane parts of extracts.
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来源期刊
Eurasian Journal of Biosciences
Eurasian Journal of Biosciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍: EurAsian Journal of BioSciences (Abbrev. Eurasia J Biosci or EJOBIOS) is an international, refereed electronic journal. It publishes the results of original research in the field of biological sciences restricted tomorphology, physiology, genetics, taxonomy, ecology and biogeography of both prokaryotic and eucaryotic organisms. The journal encourages submission of manuscripts dealing with plant biology, animal biology, plant physiology, microbiology, hydrobiology, ecology and environmental science, ethnobiology, biodiversity and conservation biology. EurAsian Journal of BioSciences publishes original articles in the following areas: -Agriculture, Fisheries & Food -Anatomy & Morphology -Behavioural Sciences -Biology, Biochemistry and Biotechnology -Biophysics -Biology Education -Cellular Biology and Anatomical Sciences -Ecology, Evolution & Environment -Entomology -Forestry -General Biology -Genetics & Heredity -Life Sciences - Other topics -Microbiology and Immunology -Molecular Biology -Mycology -Palaeontology -Parasitology -Pharmacology & Pharmacy -Physiology and Related Sciences -Plant Sciences -Toxicology -Veterinary Sciences -Virology -Zoology
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