Klotho蛋白防止衰老和尼古丁诱导的慢性细胞应激

Q4 Medicine New Medicine Pub Date : 2016-09-29 DOI:10.5604/14270994.1222604

Daniel Piątek, Emilia Migryt, Kamila Tuzim, Joanna Szydełko, A. Boguszewska-Czubara

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引用次数: 0

摘要

自1997年Klotho蛋白首次被发现并被命名为“抗衰老激素”以来，科学家们一直在深入研究它的生物学特性。这种蛋白质在许多代谢途径中起着重要作用，有助于减缓衰老过程。神经退行性疾病、认知功能障碍和慢性压力的患病率随着年龄的增长而增加。其他因素，如尼古丁、罗格列酮、他汀类药物、降血压药物、骨化三醇、镁、慢性心理社会压力和有氧运动对Klotho蛋白血浆浓度有影响。研究提高Klotho血浆水平的蛋白质是很重要的，因为Klotho参与了广泛的生物过程。对这种物质的进一步研究可能会为几种常见疾病的治疗带来新的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Klotho protein proteCtS againSt aging and niCotine-induCed ChroniC Cellular StreSS

From 1997, when Klotho protein was first discovered and named “the anti-aging hormone”, scientists have been thoroughly investigating its biological properties. this protein plays an important role in numerous metabolic pathways that contribute to slower ageing processes. the prevalence of neurodegenerative diseases, impairment of cognitive functions and chronic stress increases with age. additional factors, such as nicotine, rosiglitazone, statins, blood-pressure lowering drugs, calcitriol, magnesium, chronic psychosocial stress and aerobic exercises have an influence on Klotho protein plasma concentration. the research on proteins that increase Klotho plasma levels is important because of broad range of biological processes in which Klotho is engaged. Further studies on this substance could result in new possibilities of treatment for several common diseases.

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来源期刊

New Medicine Medicine-General Medicine

CiteScore

0.10

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： - New Medicine is indexed in Index Copernicus (IC value 6.60) and registered in Embase/Excerpta Medica. - It is published in English and some issues in other languages. - New Medicine covers a broad spectrum of disciplines. - New Medicine is sent to national and medical libraries in several countries all over the world and to some libraries and institutions in Poland. It is also present on medical conferences. - New Medicine is published under the patronage of Polish Society of Health Education.