{"title":"1-酰基乙酰胆碱与酰胺的便捷裂解反应","authors":"Junichiro Yamaguchi, K. Abe, T. Narushima","doi":"10.4236/IJOC.2013.33025","DOIUrl":null,"url":null,"abstract":"A cleavage reaction of 1-acylhydantoin by an amine in tetrahydrofuran at elevated temperature provided the corre-sponding amide and hydantoin in high yield. It was found that the addition of diethylaluminum chloride accelerated the cleavage reaction rate. The amide yield depended on the steric hindrance of the amine.","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"2013 1","pages":"194-197"},"PeriodicalIF":0.0000,"publicationDate":"2013-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4236/IJOC.2013.33025","citationCount":"0","resultStr":"{\"title\":\"Convenient Cleavage Reaction of 1-Acylhydantoin to Amide\",\"authors\":\"Junichiro Yamaguchi, K. Abe, T. Narushima\",\"doi\":\"10.4236/IJOC.2013.33025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A cleavage reaction of 1-acylhydantoin by an amine in tetrahydrofuran at elevated temperature provided the corre-sponding amide and hydantoin in high yield. It was found that the addition of diethylaluminum chloride accelerated the cleavage reaction rate. The amide yield depended on the steric hindrance of the amine.\",\"PeriodicalId\":64796,\"journal\":{\"name\":\"有机化学国际期刊(英文)\",\"volume\":\"2013 1\",\"pages\":\"194-197\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4236/IJOC.2013.33025\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"有机化学国际期刊(英文)\",\"FirstCategoryId\":\"1089\",\"ListUrlMain\":\"https://doi.org/10.4236/IJOC.2013.33025\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"有机化学国际期刊(英文)","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.4236/IJOC.2013.33025","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Convenient Cleavage Reaction of 1-Acylhydantoin to Amide
A cleavage reaction of 1-acylhydantoin by an amine in tetrahydrofuran at elevated temperature provided the corre-sponding amide and hydantoin in high yield. It was found that the addition of diethylaluminum chloride accelerated the cleavage reaction rate. The amide yield depended on the steric hindrance of the amine.
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