Deep venous thrombosis in a patient with acquired factor VIII deficiency: a case report

Acquired factor VIII deficiency is a rare disorder with a high rate of morbidity and mortality, commonly presents with bruises or bleeding in patients without previous bleeding diathesis. Presentation with thrombosis is extremely rare but if it presents with thrombosis then diagnosis and management become challenging. Balance in anticoagulation and monitoring for bleeding remains the cornerstone of treatment. We are presenting a case of 60 years old female who presented with left leg swelling and diagnosed as deep venous thrombosis and started on anticoagulation. She developed hematoma on the right arm and on further workup she was diagnosed with acquired factor VIII deficiency, treated with steroid and cyclophosphamide which resulted in a good response.