荆芥叶水提物对氯胺酮致小鼠记忆损伤的认知增强作用

Q3 Biochemistry, Genetics and Molecular Biology Journal of Advanced Biotechnology and Experimental Therapeutics Pub Date : 2023-01-01 DOI:10.5455/jabet.2023.d121
Daisy Kipkemoi, A. Ireri, M. Ngugi
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引用次数: 0

摘要

治疗阿尔茨海默病(AD)和相关认知缺陷的常规疗法不能治愈,但可以缓解症状,并引起不良副作用。另外,使用草药疗法来治疗认知疾病的情况也大大增加了。蜈蚣草通常用于营养效益和神经系统疾病的管理在草药。本研究评估了荆芥叶水提物对氯胺酮诱导的ad样认知缺陷小鼠的认知增强潜力。采用被动回避测验评估步进潜伏期的认知表现。用实验动物的脑组织评价提取物的抗乙酰胆碱酯酶活性和抗氧化能力。此外,采用LC-MS测定了提取物的植物化学成分。荆芥叶的水提物在实验动物中表现出显著的对抗认知缺陷的能力。与未处理的认知损伤小鼠相比,提取物处理小鼠的跨步潜伏期显著增加(p < 0.001),证明了这一点。此外,与阴性对照小鼠相比,给予所研究提取物的认知损伤小鼠丙二醛水平和乙酰胆碱酯酶活性显著降低(p < 0.001)。这一结果证实了马蹄莲的抗氧化和抗乙酰胆碱酯酶的特性,表明其有可能减轻脑内氧化应激和增强胆碱能传递。值得注意的是,一些常规治疗认知障碍,特别是AD的药物是AChE抑制剂。所研究的提取物中含有具有抗氧化和抗乙酰胆碱酯酶活性的类黄酮和酚类植物化合物,因此其增强认知能力的作用可能归因于这些植物成分。总的来说,这项研究支持了弓形虫在认知疾病管理中的有用性。
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Cognitive enhancing properties of aqueous leaf extract of Vigna unguiculata in ketamine-induced memory damage in mice
Conventional remedies for management of Alzheimer’s disease (AD) and related cognitive deficits are not curative but relieves the symptoms and they cause adverse side effects. Alternatively, use of herbal therapies to manage cognitive illnesses has increased substantially. Vigna unguiculata is commonly utilized for nutritional benefits and management of neurological disorders in herbal medicine. The present study evaluated cognitive enhancing potential of V. unguiculata leaf aqueous extract in mice with ketamine-induced AD-like cognitive deficits. Cognitive performance indicated by step-through latency was assessed using passive avoidance test. Anti-acetylcholinesterase (anti-AChE) and antioxidant potential of the extract was assessed using brains of the test animals. Further, phytochemical constituents of the extracts were determined using LC-MS. Aqueous extract of V. unguiculata leaf demonstrated significant prowess to combat cognitive deficits in the test animals. This was evidenced by significantly higher (p < 0.001) step-through latencies in extract-treated mice than the untreated cognitively damaged mice. Moreover, cognitively damaged mice given the studied extract exhibited significantly less (p < 0.001) malondialdehyde levels and acetylcholinesterase activity than the negative control mice. This result confirmed antioxidant and anti-AChE properties of V. unguiculata, indicating its potential to attenuate oxidative stress in the brain and augment cholinergic transmission. Notably, some conventional therapies for cognitive disorders especially AD are AChE inhibitors. The studied extract contained phytocompounds such as flavonoids and phenolics with confirmed antioxidant and anti-AChE activities, thus, its cognitive enhancing efficacy could be attributed to these phytoconstituents. Collectively, this study upholds V. ungiculata usefulness in management of cognitive illnesses.
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来源期刊
Journal of Advanced Biotechnology and Experimental Therapeutics
Journal of Advanced Biotechnology and Experimental Therapeutics Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.90
自引率
0.00%
发文量
41
审稿时长
8 weeks
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