口服片-儿科患者符合剂型

S. Malke, S. Shidhaye, J. Desai, V. Kadam
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引用次数: 26

摘要

儿童和老年患者,有困难吞咽或咀嚼固体剂型。许多儿童和老年患者不愿意采取坚实的准备,因为害怕窒息。即使是速溶片剂,由于片剂的外观,人们也担心会窒息。因此,在这种情况下,口服薄膜给药是更好的选择。口服薄膜是用聚合物、增塑剂、香精、色素和甜味剂配制的。采用溶剂铸造法、轧制法、挤压法和固体分散法制造口腔膜。对薄膜的尺寸、崩解、溶解、拉伸强度和折叠耐久性进行了评价。它具有多种用途,如掩味、即刻释放和缓释配方
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Oral Films - Patient Compliant Dosage Form For Pediatrics
Pediatric and geriatric patients, have difficulty swallowing or chewing solid dosage forms. Many pediatric and geriatric patients are unwilling to take solid preparations due to fear of choking. Even with fast dissolving tablets there is a fear of choking due to its tablet type appearance. Hence oral film drug delivery is a better alternative in such cases. The oral films are formulated using polymers, plasticizers, flavors, colors and sweeteners. The oral films are manufactured using solvent casting method, rolling method, extrusion method and solid dispersion method. The films are evaluated for dimensions, disintegration, dissolution, tensile strength and folding endurance. It has many applications like in taste masking, immediate release and sustained release formulation
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