SARS-COV-2诱导肺损伤从基础研究到临床研究

Jinguo Zhu
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摘要

截至2021年7月底,全球SARS-CoV-2感染病例已超过19490.9万例,死亡病例超过417万例。该病毒攻击人的肺泡,引起严重的肺损伤(COVID-19病)并迅速传播。COVID-19疾病的机制尚不清楚。为了更好地了解该病,本文分析了SARS-CoV-2的生物学特性,考察了其对肺泡上皮及其邻近微血管内皮的影响,探讨了人宿主细胞的免疫反应和免疫血栓形成。解释新冠肺炎相关肺损伤的临床表现。这可能有助于制定COVID-19相关肺损伤的管理策略。
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SARS-COV-2 Induce Pulmonary Injury from Basic to Clinical Research
The SARS-CoV-2 has infected over 194,909,000 cases and over 4,170,000 deaths in the world before the end of July 2021. The virus attacks human alveoli and induces severe lung injury (COVID-19 disease) and spreads rapidly. The mechanisms of COVID-19 disease are unclear. To better understand this disease, This review analyzes the SARS-CoV-2 biological characteristics, in-sights the effect of alveolar epithelium and its adjacent microvascular endothelium, investigates human host cells immune response and immunothrombosis. Explains clinical manifestations of COVID-19 associated lung injury. It may be helpful for development management strategies for COVID-19 associated pulmonary damage.
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