一种新型导尿管生物材料

R. S. Lima, S. Lima, J. Aguiar, Eziel Cavalcanti Vasconcelos Rocha, F. C. M. Pinto
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引用次数: 1

摘要

一些研究认为理想的导尿管生物材料是乌托邦式的。根据文献综述,这似乎是正确的。然而,研究进展:生物材料本身,新设计,新涂层,相关药物等。一旦植入并与尿液相互作用,两个老问题仍然存在:结痂和细菌定植。在这种情况下,细菌合成甘蔗糖蜜生物材料的细胞外产物已经在一些实验和临床研究中进行了研究。基于其高生物相容性,本研究的目的是在体内模型中评估其作为Wistar大鼠膀胱内植入的泌尿系统假体的性能。我们评估物理,化学和生物现象,比较已经建立的生物材料,聚氨酯。尽管它不是成品,但甘蔗生物聚合物在几个分析参数中表现出与聚氨酯相似的性能,并且具有一个重要特征:低成本。
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A New Biomaterial for Urinary Catheters
Several studies argue that an ideal biomaterial for urinary catheters is utopian. Based in literature review it seems to be true. However, research advances: the biomaterial itself, new designs, new coatings, associated drugs, etc. Once implanted and interacting with urine, two old problems persist: encrustation and bacterial colonization. In this context, an extracellular product from bacterial synthesis on sugarcane molasses biomaterial has been studied in several experimental and clinical studies. Based on its high biocompatibility, the aim of this study is to evaluate its performance in an in vivo model as an endourologic prosthesis implanted in the bladder of Wistar rats. We evaluate physical, chemical and biological phenomena in comparison to an already established biomaterial, polyurethane. Even though it is not a finished product, the sugarcane biopolymer presented similar performance compared to polyurethane in several analyzed parameters and has an important characteristic: low cost.
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