{"title":"RNA干扰","authors":"Kong Xiangping, Pla Air","doi":"10.5772/60631","DOIUrl":null,"url":null,"abstract":"The phenomenon of RNA interference (RNAi) is highly conserved mechanism in the organism evolution. As a immune system ,RNAi is a ubiquitous mechanism against invading microorganism in plant and animal cells. Recently, it has been found that RNAi is the process by which double-strand RNA(dsRNA) directs sequence-specific degradation of messenger RNA and the mediations of sequence specific messenger RNA degradation are 21-and 23-nucleotide small interfering RNAs that generate by ribonuclease from endogenous longer dsRNA or by transfectious technics from heterologous dsRNA. Over the past few years, the way in which cells respond to dsRNA by silencing homologous genes has revealed a new regulating paradigm in biology.","PeriodicalId":10222,"journal":{"name":"中国病理生理杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"The RNA interference\",\"authors\":\"Kong Xiangping, Pla Air\",\"doi\":\"10.5772/60631\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The phenomenon of RNA interference (RNAi) is highly conserved mechanism in the organism evolution. As a immune system ,RNAi is a ubiquitous mechanism against invading microorganism in plant and animal cells. Recently, it has been found that RNAi is the process by which double-strand RNA(dsRNA) directs sequence-specific degradation of messenger RNA and the mediations of sequence specific messenger RNA degradation are 21-and 23-nucleotide small interfering RNAs that generate by ribonuclease from endogenous longer dsRNA or by transfectious technics from heterologous dsRNA. Over the past few years, the way in which cells respond to dsRNA by silencing homologous genes has revealed a new regulating paradigm in biology.\",\"PeriodicalId\":10222,\"journal\":{\"name\":\"中国病理生理杂志\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中国病理生理杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5772/60631\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国病理生理杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5772/60631","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The phenomenon of RNA interference (RNAi) is highly conserved mechanism in the organism evolution. As a immune system ,RNAi is a ubiquitous mechanism against invading microorganism in plant and animal cells. Recently, it has been found that RNAi is the process by which double-strand RNA(dsRNA) directs sequence-specific degradation of messenger RNA and the mediations of sequence specific messenger RNA degradation are 21-and 23-nucleotide small interfering RNAs that generate by ribonuclease from endogenous longer dsRNA or by transfectious technics from heterologous dsRNA. Over the past few years, the way in which cells respond to dsRNA by silencing homologous genes has revealed a new regulating paradigm in biology.
期刊介绍：
Chinese Journal of Pathophysiology is the only comprehensive advanced academic journal of pathophysiology in China, which is supervised by China Association for Science and Technology, sponsored by Chinese Pathophysiology Society and hosted by Jinan University. Journal of pathophysiology research (including experimental research and clinical research), thematic reviews, experimental technology innovation and improvement, focusing on the introduction of disease pathogenesis.
The current Chinese Journal of Science Pathophysiology has been included in the core Database of China Science Citation Database (CSCD), CNKI, Wanfang, Vipp, Superstar, Scopus, EBSCO, Chemical Abstracting (CA), JST, WHO Western Pacific Regional Medical Index (W PRIM) and other databases included.
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