靶向癌症脱铁症:策略与机遇。

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2023-10-30 DOI:10.1111/imr.13280
Jiahan Le, Guangzhao Pan, Che Zhang, Yitao Chen, Amit K. Tiwari, Jiang-Jiang Qin
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引用次数: 0

摘要

脱铁症是一种新形式的程序性细胞死亡,在形态学、遗传学和生化上与其他细胞死亡途径不同,其特征是铁依赖性脂质过氧化物的积累和氧化损伤。现在已经知道,脱铁性贫血在各种生物过程中发挥着重要作用,尤其是在铁、脂质和氨基酸的代谢中。癌症是世界范围内普遍存在的恶性肿瘤,早期诊断率低,转移率高,预后相对较差。尽管化疗通常用于治疗GC,但耐药性往往会导致较差的治疗结果。在过去几年中,对脱铁症的广泛研究突出了其在GC治疗中的巨大潜力,为解决与标准癌症治疗相关的耐药性提供了一种有前景的策略。在这篇综述中,我们对与脱铁性贫血机制相关的关键调控因素进行了广泛的总结。特异性靶向脱铁性贫血的各种诱导剂和抑制剂被发现。此外,我们探讨了这些药物在GC治疗领域的前瞻性应用和结果,强调了它们改善该患者群体结果的能力。
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Targeting ferroptosis in gastric cancer: Strategies and opportunities

Ferroptosis is a novel form of programmed cell death morphologically, genetically, and biochemically distinct from other cell death pathways and characterized by the accumulation of iron-dependent lipid peroxides and oxidative damage. It is now understood that ferroptosis plays an essential role in various biological processes, especially in the metabolism of iron, lipids, and amino acids. Gastric cancer (GC) is a prevalent malignant tumor worldwide with low early diagnosis rates and high metastasis rates, accounting for its relatively poor prognosis. Although chemotherapy is commonly used to treat GC, drug resistance often leads to poor therapeutic outcomes. In the last several years, extensive research on ferroptosis has highlighted its significant potential in GC therapy, providing a promising strategy to address drug resistance associated with standard cancer therapies. In this review, we offer an extensive summary of the key regulatory factors related to the mechanisms underlying ferroptosis. Various inducers and inhibitors specifically targeting ferroptosis are uncovered. Additionally, we explore the prospective applications and outcomes of these agents in the field of GC therapy, emphasizing their capacity to improve the outcomes of this patient population.

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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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