降低口服抗凝治疗患者的出血风险。

IF 1.8 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 Epub Date: 2023-12-13 DOI:10.1080/14779072.2023.2275662
Eva Soler-Espejo, María Asunción Esteve-Pastor, José Miguel Rivera-Caravaca, Vanessa Roldan, Francisco Marín
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引用次数: 0

摘要

引言:口服抗凝(OAC)显著降低了心房颤动(AF)和静脉血栓栓塞(VTE)患者的血栓栓塞风险,但对重大出血事件的担忧仍然存在。事实上,临床相关的出血可能会危及生命。出血风险是动态的,受年龄、新合并症和药物治疗等因素的影响,不应仅根据静态基线因素进行评估。涵盖领域:我们全面回顾了OAC治疗相关的出血风险。强调评估血栓栓塞和出血风险的重要性,我们提出了评估AF和VTE患者中风和系统性栓塞(SSE)以及出血风险的临床工具。我们还讨论了重叠的风险因素和出血风险的动态性质。专家意见:OAC管理正在经历不断的变革,其主要目标是减轻血栓栓塞和出血风险,从而在整个治疗过程中提高患者的安全性。在先进的病理生理学见解和技术进步的推动下,OAC的未来包括个性化方法和创新疗法。这有望改善患者的治疗效果,彻底改变抗凝治疗方法。
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Reducing bleeding risk in patients on oral anticoagulation therapy.

Introduction: Oral anticoagulation (OAC) significantly mitigates thromboembolism risks in atrial fibrillation (AF) and venous thromboembolism (VTE) patients yet concern about major bleeding events persist. In fact, clinically relevant hemorrhages can be life-threatening. Bleeding risk is dynamic and influenced by factors such as age, new comorbidities, and drug therapies, and should not be assessed solely based on static baseline factors.

Areas covered: We comprehensively review the bleeding risk associated with OAC therapy. Emphasizing the importance of assessing both thromboembolic and bleeding risks, we present clinical tools for estimating stroke and systemic embolism (SSE) and bleeding risk in AF and VTE patients. We also address overlapping risk factors and the dynamic nature of bleeding risk.

Expert opinion: The OAC management is undergoing constant transformation, motivated by the primary objective of mitigating thromboembolism and bleeding hazards, thereby amplifying patient safety throughout the course of treatment. The future of OAC embraces personalized approaches and innovative therapies, driven by advanced pathophysiological insights and technological progress. This holds promise for improving patient outcomes and revolutionizing anticoagulation practices.

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来源期刊
Expert Review of Cardiovascular Therapy
Expert Review of Cardiovascular Therapy CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
0.00%
发文量
82
期刊介绍: Expert Review of Cardiovascular Therapy (ISSN 1477-9072) provides expert reviews on the clinical applications of new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage includes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery. The Expert Review format is unique. Each review provides a complete overview of current thinking in a key area of research or clinical practice.
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