铁蛋白吞噬：治疗脱铁性肝病的新思路。

IF 3.6 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Hepatobiliary & Pancreatic Diseases International Pub Date : 2023-10-20 DOI:10.1016/j.hbpd.2023.10.005

Zi-Bing Qian , Jun-Feng Li , Wan-Yuan Xiong , Xiao-Rong Mao

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引用次数: 0

摘要

背景：调节性细胞死亡的发现导致了治疗领域的突破。各种形式的细胞死亡，如坏死、细胞凋亡、pyroptosis、自噬和ferroptosis，在肝病的发展中起着重要作用。一般来说，多种形式的细胞死亡途径是导致疾病状态的原因。因此，研究肝脏疾病中各种细胞死亡形式的调节和相互作用尤为重要。数据来源：截至2022年11月，我们使用以下关键词进行了PubMed搜索：铁蛋白吞噬、脱铁性贫血和肝病。我们还使用了信号路径、诱导器和抑制剂等术语来补充查询结果。结果：本文综述了铁蛋白吞噬和脱铁性贫血的基本特征以及铁蛋白吞噬对脱铁性肝病的调节，并综述了不同肝病中脱铁性肝炎的关键靶点和治疗策略。结论：铁蛋白吞噬是治疗脱铁性肝病的潜在靶点。

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Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

Background

The discovery of regulatory cell death has led to a breakthrough in the therapeutic field. Various forms of cell death, such as necrosis, apoptosis, pyroptosis, autophagy, and ferroptosis, play an important role in the development of liver diseases. In general, more than one form of cell death pathways is responsible for the disease state. Therefore, it is particularly important to study the regulation and interaction of various cell death forms in liver diseases.

Data sources

We performed a PubMed search up to November 2022 with the following keywords: ferritinophagy, ferroptosis, and liver disease. We also used terms such as signal path, inducer, and inhibitor to supplement the query results.

Results

This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver diseases.

Conclusions

Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

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来源期刊

Hepatobiliary & Pancreatic Diseases International 医学-胃肠肝病学

CiteScore

5.40

自引率

6.10%

发文量

152

审稿时长

3.0 months

期刊介绍： Hepatobiliary & Pancreatic Diseases International (HBPD INT) (ISSN 1499-3872 / CN 33-1391/R) a bimonthly journal published by First Affiliated Hospital, Zhejiang University School of Medicine, China. It publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic diseases. Papers cover the medical, surgical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas under the headings Liver, Biliary, Pancreas, Transplantation, Research, Special Reports, Editorials, Review Articles, Brief Communications, Clinical Summary, Clinical Images and Case Reports. It also deals with the basic sciences and experimental work. The journal is abstracted and indexed in SCI-E, IM/MEDLINE, EMBASE/EM, CA, Scopus, ScienceDirect, etc.