【Kalirin-7在运动干预介导的神经退行性疾病改善中的作用研究进展】。

Q3 Medicine 生理学报 Pub Date : 2023-10-25

Meng-Yuan Yu, Zhen-Jun Tian

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引用次数: 0

摘要

鸟嘌呤核苷酸交换因子Kalin-7（Kal-7）是突触可塑性的关键因子，在大脑中起着重要的调节作用。突触功能异常导致学习记忆等认知功能减弱，并伴有Kal-7的异常表达，进而诱发多种神经退行性疾病。运动可以上调大脑相关区域Kal-7的表达，以缓解神经退行性疾病。通过回顾Kal-7与神经退行性疾病的相关文献以及运动干预的研究进展，总结了Kal-7在运动改善神经退行性病变中的作用及其可能机制，为运动防治神经退行性病的基础和临床研究提供了新的理据。

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[Progress on the role of Kalirin-7 in exercise intervention-mediated improvement of neurodegenerative diseases].

Guanine nucleotide exchange factor Kalirin-7 (Kal-7) is a key factor in synaptic plasticity and plays an important regulatory role in the brain. Abnormal synaptic function leads to the weakening of cognitive functions such as learning and memory, accompanied by abnormal expression of Kal-7, which in turn induces a variety of neurodegenerative diseases. Exercise can upregulate the expression of Kal-7 in related brain regions to alleviate neurodegenerative diseases. By reviewing the literature on Kal-7 and neurodegenerative diseases, as well as the research progress of exercise intervention, this paper summarizes the role and possible mechanism of Kal-7 in the improvement of neurodegenerative diseases by exercise and provides a new rationale for the basic and clinical research on the prevention and treatment of neurodegenerative diseases by exercise.

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.